Tumor Budding Score Is a Strong and Independent Prognostic Factor in Patients With Pancreatic Ductal Adenocarcinoma: An Evaluation of Whole Slide Pathology Images of Large Sections

被引：2
作者：
Jiang, Hui [1 ]
Yang, Yelin [1 ]
Qian, Yuping [1 ]
Shao, Chengwei [2 ]
Lu, Jianping [2 ]
Bian, Yun [2 ]
Zheng, Jianming [1 ]
机构：
[1] Naval Mil Med Univ, Changhai Hosp, Dept Pathol, Shanghai, Peoples R China
[2] Naval Med Univ, Changhai Hosp, Dept Radiol, Shanghai, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2021年 / 11卷
基金：
美国国家科学基金会; 上海市自然科学基金;
关键词：
pancreatic neoplasm; carcinoma; tumor budding; prognosis; survival; neoplasm staging; CANCER; VALIDATION; EXPRESSION; INVASION;
D O I：
10.3389/fonc.2021.740212
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
ObjectiveWe aimed to develop the tumor budding (TB) score and to explore the association between the TB score and overall survival (OS) in patients with pancreatic ductal adenocarcinoma (PDAC). MethodsIn this retrospective study, 130 consecutive patients with PDAC underwent surgical resection between July 2016 and March 2019. The location and counts of TB were assessed based on the digitalized whole slide hematoxylin and eosin images. The TB score was achieved using the Cox regression equation. The cutoff point for the TB score was determined by X-tile. Univariate and multivariate Cox regression models were used to analyze the association between the TB score and OS. ResultsThe TB score was 0.49 (range = 0-1.08), and the best cutoff for the TB score was 0.62. The duration of survival in individuals with a low TB score [median = 21.8 months, 95% confidence interval (CI) = 15.43-25.50] was significantly longer than that in those with a high TB score (median = 11.33 months, 95% CI = 9.8-14.22). Univariate analysis revealed that the TB score was significantly associated with OS [hazard ratio (HR) = 2.71, 95% CI = 1.48-4.96, p = 0.001]. Multivariate analysis revealed a strong and independent association between the TB score and OS (HR = 2.35, 95% CI = 1.27-4.33, p = 0.03). The high TB score group had a 2.14 times higher mortality than the low TB score group. ConclusionThe TB score is strongly and independently associated with the risk of OS in PDAC.
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页数：10
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