Microdosimetry of the Auger electron emitting 123I radionuclide using Geant4-DNA simulations

被引：20
作者：
Fourie, H. [1 ]
Newman, R. T. [1 ]
Slabbert, J. P. [2 ]
机构：
[1] Univ Stellenbosch, Dept Phys, ZA-7602 Stellenbosch, South Africa
[2] iThemba LABS NRF, ZA-7129 Somerset West, South Africa
来源：
PHYSICS IN MEDICINE AND BIOLOGY | 2015年 / 60卷 / 08期
基金：
新加坡国家研究基金会;
关键词：
microdosimetry; auger electrons; Geant4-DNA; Monte Carlo; SINGLE-CELL DOSIMETRY; MONTE-CARLO; ABSORBED FRACTIONS; ENERGY DEPOSITION; LIQUID WATER; S-VALUES; RADIOIMMUNOTHERAPY; RADIOTOXICITY; SPECTRA; SPHERES;
D O I：
10.1088/0031-9155/60/8/3333
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Microdosimetric calculations of the Auger electron emitter I-123 were done in liquid water spheres using the Geant4 toolkit. The electron emission spectrum of 123I produced by Geant4 is presented. Energy deposition and corresponding S-values were calculated to investigate the influence of the sub-cellular localization of the Auger emitter. It was found that S-values calculated by the Geant4 toolkit are generally lower than the values calculated by other Monte Carlo codes for the I-123 radionuclide. The differences in the compared S-values are mainly due to the different particle emission spectra employed by the respective computational codes and emphasizes the influence of the spectra on dosimetry calculations.
引用
收藏
页码：3333 / 3346
页数：14
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