The influence of low-grade glioma on resting state oscillatory brain activity: a magnetoencephalography study

被引：39
作者：
Bosma, I. [1 ]
Stam, C. J. [2 ]
Douw, L. [3 ]
Bartolomei, F. [4 ]
Heimans, J. J. [1 ]
van Dijk, B. W. [5 ]
Postma, T. J. [1 ]
Klein, M. [3 ]
Reijneveld, J. C. [1 ,6 ]
机构：
[1] Vrije Univ Amsterdam Med Ctr, Dept Neurol, NL-1081 HV Amsterdam, Netherlands
[2] Vrije Univ Amsterdam Med Ctr, Dept Clin Neurophysiol, NL-1081 HV Amsterdam, Netherlands
[3] Vrije Univ Amsterdam Med Ctr, Dept Med Psychol, NL-1081 HV Amsterdam, Netherlands
[4] Ctr Hosp Univ Timone, Dept Clin Neurophysiol & Epileptol, Marseille, France
[5] Vrije Univ Amsterdam Med Ctr, Magnetoencephalog Ctr, NL-1081 HV Amsterdam, Netherlands
[6] Univ Amsterdam, Acad Med Ctr, Dept Neurol, NL-1105 AZ Amsterdam, Netherlands
来源：
JOURNAL OF NEURO-ONCOLOGY | 2008年 / 88卷 / 01期
关键词：
low-grade glioma; cognition; MEG; power analysis;
D O I：
10.1007/s11060-008-9535-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose In the present MEG-study, power spectral analysis of oscillatory brain activity was used to compare resting state brain activity in both low-grade glioma (LGG) patients and healthy controls. We hypothesized that LGG patients show local as well as diffuse slowing of resting state brain activity compared to healthy controls and that particularly global slowing correlates with neurocognitive dysfunction. Patient and methods Resting state MEG recordings were obtained from 17 LGG patients and 17 age-, sex-, and education-matched healthy controls. Relative spectral power was calculated in the delta, theta, upper and lower alpha, beta, and gamma frequency band. A battery of standardized neurocognitive tests measuring 6 neurocognitive domains was administered. Results LGG patients showed a slowing of the resting state brain activity when compared to healthy controls. Decrease in relative power was mainly found in the gamma frequency band in the bilateral frontocentral MEG regions, whereas an increase in relative power was found in the theta frequency band in the left parietal region. An increase of the relative power in the theta and lower alpha band correlated with impaired executive functioning, information processing, and working memory. Conclusion LGG patients are characterized by global slowing of their resting state brain activity and this slowing phenomenon correlates with the observed neurocognitive deficits.
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页码：77 / 85
页数：9
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