Autoimmune polyglandular diseases

被引：35

作者：

Kahaly, George J. ^{[1
]}

Frommer, Lara ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Dept Med 1, Med Ctr, Mainz, Germany

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2019年 / 33卷 / 06期

关键词：

autoimmune polyglandular disease; pathophysiology; familial clustering; psychosocial morbidity; management; REGULATORY T-CELLS; THYROID-STIMULATING IMMUNOGLOBULINS; IMMUNOLOGICAL SELF-TOLERANCE; CLINICAL-RELEVANCE; SYNDROME TYPE-2; GRAVES-DISEASE; ASSOCIATION; ANTIBODIES; AUTOANTIBODIES; POLYMORPHISM;

D O I：

10.1016/j.beem.2019.101344

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autoimmune polyglandular diseases (APD) are defined as the presence of two autoimmune -induced endocrine failures. With respect to the significant morbidity and potential mortality of APD, the diagnostic objective is to detect APD at an early stage, with the advantage of less frequent complications, effective therapy and better prognosis. This requires that patients at risk be regularly screened for subclinical endocrinopathies prior to clinical manifestation. Regarding the time interval between manifestation of first and further endocrinopathies, regular and long-term followup is warranted. Quality of life and psychosocial status are poor in APD patients and involved relatives. Familial clustering is high in patients with APD. Considering the high incidence of one or more endocrinopathies in first-degree relatives of patients with APD, family members should be regularly screened since they may also develop autoimmune endocrinopathies. Multidisciplinary management of these multiplex families in specialized centers is warranted. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页数：12

共 73 条

[21] Genetics of the Autoimmune Polyglandular Syndrome Type 3 Variant [J].

Dittmar, Manuela ;

Kahaly, George J. .

THYROID, 2010, 20 (07) :737-743

[22] The Proinflammatory Cytokine TNF-α-308 AA Genotype is Associated with Polyglandular Autoimmunity [J].

Dittmar, Manuela ;

Kaczmarczyk, Adam ;

Bischofs, Christian ;

Kahaly, George J. .

IMMUNOLOGICAL INVESTIGATIONS, 2009, 38 (3-4) :255-267

[23] A novel mutation in the DNASE1 gene is related with protein instability and decreased enzyme activity in thyroid autoimmunity [J].

Dittmar, Manuela ;

Bischofs, Christian ;

Matheis, Nina ;

Poppe, Robert ;

Kahaly, George J. .

JOURNAL OF AUTOIMMUNITY, 2009, 32 (01) :7-13

[24] CTLA-4 CT60 Polymorphism in Thyroid and Polyglandular Autoimmunity [J].

Dultz, G. ;

Matheis, N. ;

Dittmar, M. ;

Bender, K. ;

Kahaly, G. J. .

HORMONE AND METABOLIC RESEARCH, 2009, 41 (06) :426-429

[25] The Protein Tyrosine Phosphatase Non-Receptor Type 22 C1858T Polymorphism Is a Joint Susceptibility Locus for Immunthyroiditis and Autoimmune Diabetes [J].

Dultz, Georg ;

Matheis, Nina ;

Dittmar, Manuela ;

Roehrig, Bernd ;

Bender, Klaus ;

Kahaly, George J. .

THYROID, 2009, 19 (02) :143-148

[26] Medical progress - Autoimmune polyendocrine syndromes [J].

Eisenbarth, GS ;

Gottlieb, PA .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (20) :2068-2079

[27]

EISENBARTH GS, 1986, NEW ENGL J MED, V314, P1360

[28] HLA Class II Haplotypes Differentiate Between the Adult Autoimmune Polyglandular Syndrome Types II and III [J].

Flesch, B. K. ;

Matheis, N. ;

Alt, T. ;

Weinstock, C. ;

Bux, J. ;

Kahaly, G. J. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2014, 99 (01) :E177-E182

[29] Sex Alters the MHC Class I HLA-A Association With Polyglandular Autoimmunity [J].

Flesch, Brigitte K. ;

Koenig, Jochem ;

Frommer, Lara ;

Hansen, Martin P. ;

Kahaly, George J. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2019, 104 (05) :1680-1686

[30] Polyglandular autoimmune syndrome type II:: epidemiology and forms of manifestation [J].

Förster, G ;

Krummenauer, F ;

Kühn, I ;

Beyer, J ;

Kahaly, G .

DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 1999, 124 (49) :1476-1481

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