Autoimmune polyglandular diseases

被引：35

作者：

Kahaly, George J. ^{[1
]}

Frommer, Lara ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Dept Med 1, Med Ctr, Mainz, Germany

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2019年 / 33卷 / 06期

关键词：

autoimmune polyglandular disease; pathophysiology; familial clustering; psychosocial morbidity; management; REGULATORY T-CELLS; THYROID-STIMULATING IMMUNOGLOBULINS; IMMUNOLOGICAL SELF-TOLERANCE; CLINICAL-RELEVANCE; SYNDROME TYPE-2; GRAVES-DISEASE; ASSOCIATION; ANTIBODIES; AUTOANTIBODIES; POLYMORPHISM;

D O I：

10.1016/j.beem.2019.101344

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autoimmune polyglandular diseases (APD) are defined as the presence of two autoimmune -induced endocrine failures. With respect to the significant morbidity and potential mortality of APD, the diagnostic objective is to detect APD at an early stage, with the advantage of less frequent complications, effective therapy and better prognosis. This requires that patients at risk be regularly screened for subclinical endocrinopathies prior to clinical manifestation. Regarding the time interval between manifestation of first and further endocrinopathies, regular and long-term followup is warranted. Quality of life and psychosocial status are poor in APD patients and involved relatives. Familial clustering is high in patients with APD. Considering the high incidence of one or more endocrinopathies in first-degree relatives of patients with APD, family members should be regularly screened since they may also develop autoimmune endocrinopathies. Multidisciplinary management of these multiplex families in specialized centers is warranted. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页数：12

共 73 条

[1] AN AUTOSOMAL LOCUS CAUSING AUTOIMMUNE-DISEASE - AUTOIMMUNE POLYGLANDULAR DISEASE TYPE-I ASSIGNED TO CHROMOSOME-21 [J].

AALTONEN, J ;

BJORSES, P ;

SANDKUIJL, L ;

PERHEENTUPA, J ;

PELTONEN, L .

NATURE GENETICS, 1994, 8 (01) :83-87

[2]

[Anonymous], J KLIN ENDOKRINOL ST

[3] HLA Class II Differentiates Between Thyroid and Polyglandular Autoimmunity [J].

Beradhi, S. Barkia ;

Flesch, B. K. ;

Hansen, M. P. ;

Matheis, N. ;

Kahaly, G. J. .

HORMONE AND METABOLIC RESEARCH, 2016, 48 (04) :232-237

[4] Autoimmune polyglandular syndrome Type 2: the tip of an iceberg? [J].

Betterle, C ;

Lazzarotto, F ;

Presotto, F .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2004, 137 (02) :225-233

[5] Autoantibodies to steroidogenic enzymes in autoimmune polyglandular syndrome, Addison's disease, and premature ovarian failure [J].

Chen, S ;

Sawicka, J ;

Betterle, C ;

Powell, M ;

Prentice, L ;

Volpato, M ;

Smith, BR ;

Furmaniak, J .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (05) :1871-1876

[6] Distinct idiotypes of insulin autoantibody in autoimmune polyendocrine syndrome type 2 and childhood onset type 1 diabetes [J].

Devendra, D ;

Franke, B ;

Galloway, TS ;

Horton, SJ ;

Knip, M ;

Wilkin, TJ .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (10) :5266-5270

[7]

Devendra Devasenan, 2003, Journal of Allergy and Clinical Immunology, V111, pS624

[8] Prevalence and clinical relevance of thyroid stimulating hormone receptor-blocking antibodies in autoimmune thyroid disease [J].

Diana, T. ;

Krause, J. ;

Olivo, P. D. ;

Koenig, J. ;

Kanitz, M. ;

Decallonne, B. ;

Kahaly, G. J. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2017, 189 (03) :304-309

[9] Highly variable sensitivity of five binding and two bio-assays for TSH-receptor antibodies [J].

Diana, T. ;

Wuester, C. ;

Kanitz, M. ;

Kahaly, G. J. .

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2016, 39 (10) :1159-1165

[10] Clinical Relevance of Thyroid-Stimulating Autoantibodies in Pediatric Graves' Disease-A Multicenter Study [J].

Diana, T. ;

Brown, R. S. ;

Bossowski, A. ;

Segni, M. ;

Niedziela, M. ;

Koenig, J. ;

Bossowska, A. ;

Ziora, K. ;

Hale, A. ;

Smith, J. ;

Pitz, S. ;

Kanitz, M. ;

Kahaly, G. J. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2014, 99 (05) :1648-1655

← 1 2 3 4 5 6 7 8 →