TET2 Deficiency Sets the Stage for B-cell Lymphoma

被引：8

作者：

Shingleton, Jennifer R. ^{[1
]}

Dave, Sandeep S. ^{[1
]}

机构：

[1] Duke Univ, Canc Genet & Genom Program, Duke Canc Inst, Ctr Genom & Computat Biol, Durham, NC 27708 USA

来源：

CANCER DISCOVERY | 2018年 / 8卷 / 12期

关键词：

MUTATIONS;

D O I：

10.1158/2159-8290.CD-18-1143

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

TET2 is a well-established tumor suppressor in the context of myeloid malignancies, but its role in lymphoma development has been less clear. In this issue of Cancer Discovery, Dominguez and colleagues report that TET2 function is critical for germinal center exit and plasma cell differentiation, and its deficiency can lead to B-cell lymphoma phenotypes. (c) 2018 AACR.

引用

页码：1515 / 1517

页数：3

共 9 条

[1] Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies [J].

Abdel-Wahab, Omar ;

Mullally, Ann ;

Hedvat, Cyrus ;

Garcia-Manero, Guillermo ;

Patel, Jay ;

Wadleigh, Martha ;

Malinge, Sebastien ;

Yao, JinJuan ;

Kilpivaara, Outi ;

Bhat, Rukhmi ;

Huberman, Kety ;

Thomas, Sabrena ;

Dolgalev, Igor ;

Heguy, Adriana ;

Paietta, Elisabeth ;

Le Beau, Michelle M. ;

Beran, Miloslav ;

Tallman, Martin S. ;

Ebert, Benjamin L. ;

Kantarjian, Hagop M. ;

Stone, Richard M. ;

Gilliland, D. Gary ;

Crispino, John D. ;

Levine, Ross L. .

BLOOD, 2009, 114 (01) :144-147

[2] Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma [J].

Asmar, Fazila ;

Punj, Vasu ;

Christensen, Jesper ;

Pedersen, Marianne T. ;

Pedersen, Anja ;

Nielsen, Anders B. ;

Hother, Christoffer ;

Ralfkiaer, Ulrik ;

Brown, Peter ;

Ralfkiaer, Elisabeth ;

Helin, Kristian ;

Grenbaek, Kirsten .

HAEMATOLOGICA, 2013, 98 (12) :1912-1920

[3] Role of DNMT3A, TET2, and IDH1/2 mutations in pre-leukemic stem cells in acute myeloid leukemia [J].

Chan, Steven M. ;

Majeti, Ravindra .

INTERNATIONAL JOURNAL OF HEMATOLOGY, 2013, 98 (06) :648-657

[4] Dysregulation of TET2 in hematologic malignancies [J].

Chiba, Shigeru .

INTERNATIONAL JOURNAL OF HEMATOLOGY, 2017, 105 (01) :17-22

[5] Mutation in TET2 in Myeloid Cancers [J].

Delhommeau, Francois ;

Dupont, Sabrina ;

Della Valle, Veronique ;

James, Chloe ;

Trannoy, Severine ;

Masse, Aline ;

Kosmider, Olivier ;

Le Couedic, Jean-Pierre ;

Robert, Fabienne ;

Alberdi, Antonio ;

Lecluse, Yann ;

Plo, Isabelle ;

Dreyfus, Francois J. ;

Marzac, Christophe ;

Casadevall, Nicole ;

Lacombe, Catherine ;

Romana, Serge P. ;

Dessen, Philippe ;

Soulier, Jean ;

Viguie, Franck ;

Fontenay, Michaela ;

Vainchenker, William ;

Bernard, Olivier A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (22) :2289-2301

[6] TET2 Deficiency Causes Germial Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenes [J].

Dominguez, Pilar M. ;

Ghamlouch, Hussein ;

Rosikiewicz, Wojciech ;

Kumar, Parveen ;

Beguelin, Wendy ;

Fontan, Lorena ;

Rivas, Martin A. ;

Pawlikowska, Patrycja ;

Armand, Marine ;

Mouly, Enguerran ;

Torres-Martin, Miguel ;

Doane, Ashley S. ;

Fernandez, Maria T. Calvo ;

Durant, Matt ;

Della-Valle, Veronique ;

Teater, Matt ;

Cimmino, Luisa ;

Droin, Nathalie ;

Tadros, Saber ;

Motanagh, Samaneh ;

Shih, Alan H. ;

Rubin, Mark A. ;

Tam, Wayne ;

Aifantis, Iannis ;

Levine, Ross L. ;

Elemento, Olivier ;

Inghirami, Giorgio ;

Green, Michael R. ;

Figueroas, Maria E. ;

Bernard, Olivier A. ;

Aoufouchi, Said ;

Li, Sheng ;

Shaknovich, Rita ;

Melnick, Ari M. .

CANCER DISCOVERY, 2018, 8 (12) :1632-1653

[7] TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis [J].

Quivoron, Cyril ;

Couronne, Lucile ;

Della Valle, Veronique ;

Lopez, Cecile K. ;

Plo, Isabelle ;

Wagner-Ballon, Orianne ;

Do Cruzeiro, Marcio ;

Delhommeau, Francois ;

Arnulf, Bertrand ;

Stern, Marc-Henri ;

Godley, Lucy ;

Opolon, Paule ;

Tilly, Herve ;

Solary, Eric ;

Duffourd, Yannis ;

Dessen, Philippe ;

Merle-Beral, Helene ;

Florence Nguyen-Khac ;

Fontenay, Michaela ;

Vainchenker, William ;

Bastard, Christian ;

Mercher, Thomas ;

Bernard, Olivier A. .

CANCER CELL, 2011, 20 (01) :25-38

[8] Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma [J].

Reddy, Anupama ;

Zhang, Jenny ;

Davis, Nicholas S. ;

Moffitt, Andrea B. ;

Love, Cassandra L. ;

Waldrop, Alexander ;

Leppa, Sirpa ;

Pasanen, Annika ;

Meriranta, Leo ;

Karjalainen-Lindsberg, Marja-Liisa ;

Norgaard, Peter ;

Pedersen, Mette ;

Gang, Anne O. ;

Hogdall, Estrid ;

Heavican, Tayla B. ;

Lone, Waseem ;

Iqbal, Javeed ;

Qin, Qiu ;

Li, Guojie ;

Kim, So Young ;

Healy, Jane ;

Richards, Kristy L. ;

Fedoriw, Yuri ;

Bernal-Mizrachi, Leon ;

Koff, Jean L. ;

Staton, Ashley D. ;

Flowers, Christopher R. ;

Paltiel, Ora ;

Goldschmidt, Neta ;

Calaminici, Maria ;

Clear, Andrew ;

Gribben, John ;

Nguyen, Evelyn ;

Czader, Magdalena B. ;

Ondrejka, Sarah L. ;

Collie, Angela ;

Hsi, Eric D. ;

Tse, Eric ;

Au-Yeung, Rex K. H. ;

Kwong, Yok-Lam ;

Srivastava, Gopesh ;

Choi, William W. L. ;

Evens, Andrew M. ;

Pilichowska, Monika ;

Sengar, Manju ;

Reddy, Nishitha ;

Li, Shaoying ;

Chadburn, Amy ;

Gordon, Leo I. ;

Jaffe, Elaine S. .

CELL, 2017, 171 (02) :481-+

[9] The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases [J].

Solary, E. ;

Bernard, O. A. ;

Tefferi, A. ;

Fuks, F. ;

Vainchenker, W. .

LEUKEMIA, 2014, 28 (03) :485-496

← 1 →