Design, preparation and evaluation of nanoparticles of 5-Flurouracil for the targeted delivery to treat colon cancer

被引：1

作者：

Sharma, Rajiv ^{[1
]}

Ashraf, Ruhit ^{[2
,3
]}

Gill, Amandeep Kaur ^{[3
]}

Sharma, R. B. ^{[1
]}

机构：

[1] Chandigarh Univ, Univ Inst Pharma Sci, Mohali, India

[2] BIS Inst Pharmaceut Sci, Moga, India

[3] CT Univ, Sch Pharmaceut Sci, Ludhiana, Punjab, India

来源：

MATERIALS TODAY-PROCEEDINGS | 2022年 / 48卷

关键词：

Cancer; Nanoparticles; Colon cancer; PLGA;

D O I：

10.1016/j.matpr.2021.09.200

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The objective of the study is to prepare the nano particles of 5-fluorouracil with targeted delivery to the colon with enhancement of bioavailability and decrease the side effects of the drug. 5-Fluorouracilloaded PLGA nanoparticles were developed by double solvent evaporation technique method. Characterization was carried out by determination of encapsulation efficiency (%), loss on Drying. The in-vitro drug release of drug 5- Fluorouracil was carried out for formulations (F1-F4), it is concluded that F4 was the best formulation which shows the most desired rate drug release and concluded that the polymer PLGA have a capacity of protection the drug in the GI and small intestinal Fluid hence, the maximum release of drug in the colonic region of large intestine. (c) 2021 Elsevier Ltd. All rights reserved. Selection and peer-review under responsibility of the scientific committee of the Symposium on Synthesis, Characterization & Processing of Inorganic, bio and nano Materials -2021.

引用

页码：1427 / 1430

页数：4