A mapping platform for mitotic crossover by single-cell multi-omics

被引：1
|
作者：
Chovanec, Peter [1 ]
Yin, Yi [1 ]
机构：
[1] Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA 90095 USA
来源：
DNA REPLICATION-REPAIR INTERFACE | 2021年 / 661卷
基金：
美国国家卫生研究院;
关键词：
GENOME-WIDE; MUTATIONAL SIGNATURES; STRAND BREAKS; END RESECTION; INSTABILITY; REPAIR; RECOMBINATION;
D O I：
10.1016/bs.mie.2021.08.017
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Mitotic crossovers have the potential to cause large-scale genome rearrangements. Here, we describe high-throughput, single-cell, whole-genome sequencing methods for mapping crossovers genome-wide at scale. The methods are generalizable to various eukaryotes and to other end points requiring high-throughput, high-coverage single cell sequencing.
引用
收藏
页码：183 / 204
页数：22
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