共 50 条
- [1] Advances in the Discovery of Small-Molecule IRAK4 InhibitorsANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 49, 2014, 49 : 117 - 133Hynes, John, Jr.Nair, Satheesh K.
- [2] High throughput screening of IRAK4 small molecule inhibitors in TLR ligand stimulated whole bloodJOURNAL OF IMMUNOLOGY, 2018, 200 (01):Sujatha-Bhaskar, SwathiHuang, ZhiyuFrancis, GeorgeBryan, CallieZarrin, Ali A.Kiefer, JamesGhilardi, NicoBrightbill, Hans D.
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- [4] Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 26 (04) : 913 - 924Degorce, Sebastien L.Anjum, RanaDillman, Keith S.Drew, LisaGroombridge, Sam D.Halsall, Christopher T.Lenz, Eva M.Lindsay, Nicola A.Mayo, Michele F.Pink, Jennifer H.Robb, Graeme R.Scott, James S.Stokes, StephenXue, Yafeng
- [5] Development of Potent and Selective Pyrazolopyrimidine IRAK4 InhibitorsJOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (13) : 6223 - 6240Bryan, Marian C.Drobnick, JoyGobbi, AlbertoKolesnikov, AleksandrChen, YongshengRajapaksa, NaomiNdubaku, ChudiFeng, JianwenChang, WillyFrancis, RossYu, ChristineChoo, Edna F.DeMent, KevinRan, YingqingAn, LeEmson, ClaireHuang, ZhiyuSujatha-Bhaskar, SwathiBrightbill, HansDiPasquale, AntonioMaher, JonathanWai, JohnMcKenzie, Brent S.Lupardus, Patrick J.Zarrin, Ali A.Kiefer, James R.
- [6] Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitorsBIOORGANIC & MEDICINAL CHEMISTRY, 2022, 63Cumming, Iain A.Degorce, Sebastien L.Aagaard, AnnaBraybrooke, Erin L.Davies, Nichola L.Diene, Coura R.Eatherton, Andrew J.Felstead, Hannah R.Groombridge, Sam D.Lenz, Eva M.Li, YunxiaNai, YoufengPearson, StuartRobb, Graeme R.Scott, James S.Steward, Oliver R.Wu, ChengyanXue, YafengZhang, LanpingZhang, Yanxiu
- [7] Bicyclic pyrimidine compounds as potent IRAK4 inhibitorsBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2022, 73Chen, YanTso, KinHeckrodt, Thilo J.Li, HuiYen, RoseLin, NanSingh, RajinderTaylor, VanessaMasuda, Esteban S.Park, GaryPayan, Donald G.
- [8] Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (12) : 2721 - 2726Smith, Graham F.Altman, Michael D.Andresen, BrianBaker, JamesBrubaker, Jason D.Chen, HongminChen, YipingChilders, MatthewDonofrio, AnthonyFerguson, HeidiFischer, ChristianFischmann, Thierry O.Gibeau, CraigHicks, AlexanderJin, SueKattar, SamKleinschek, Melanie A.Leccese, EricaLesburg, CharlesLi, ChaominLim, JongwonLiu, DuanMaclean, John K. F.Mansoor, FarukMoy, Lilly Y.Mulrooney, Erin F.Necheva, Antoaneta S.Presland, JeremyRakhilina, LarissaYang, RuojingTorres, LuisZhang-Hoover, JieNorthrup, Alan
- [9] Identification of IRAK4-Dependent Gene Signature As a Biomarker Candidate for IRAK4 Small-Molecule Inhibitor in Systemic Lupus ErythematosusARTHRITIS & RHEUMATOLOGY, 2017, 69Setiadi, A. FrancescaSenger, KateHackney, JasonZuckerman, NetaSujatha-Bhaskar, SwathiFrancis, GeorgeBryan, MarianBrightbill, HansZarrin, Ali A.Townsend, Michael J.
- [10] Unraveling Extremely Damaging IRAK4 Variants and Their Potential Implications for IRAK4 Inhibitor EfficacyJOURNAL OF PERSONALIZED MEDICINE, 2023, 13 (12):Behairy, Mohammed Y.Eid, Refaat A.Otifi, Hassan M.Mohammed, Heitham M.Alshehri, Mohammed A.Asiri, AshwagAldehri, MajedZaki, Mohamed Samir A.Darwish, Khaled M.Elhady, Sameh S.El-Shaer, Nahla H.Eldeen, Muhammad Alaa