Design, synthesis and structure-activity relationship of novel coumarin derivatives

被引：46

作者：

Guan, Ai-Ying ^{[1
]}

Liu, Chang-Ling ^{[1
]}

Li, Miao ^{[1
]}

Zhang, Hong ^{[1
]}

Li, Zhi-Nian ^{[1
]}

Li, Zheng-Ming ^{[2
]}

机构：

[1] Shenyang Res Inst Chem Ind, State Key Lab Discovery & Dev Novel Pesticide, Shenyang 110021, Peoples R China

[2] Nankai Univ, Inst Elementoorgan Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

PEST MANAGEMENT SCIENCE | 2011年 / 67卷 / 06期

关键词：

coumarin derivatives; methoxyacrylates; intermediate derivatisation method; fungicidal activities; structure-activity relationship; STROBILURIN DERIVATIVES; FUNGICIDAL ACTIVITY; BIOLOGICAL-ACTIVITY; ACARICIDAL ACTIVITY; ALLELOCHEMICALS;

D O I：

10.1002/ps.2103

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

BACKGROUND: The lead coumarin derivative (E)-methyl 3-methoxy-2-[2-(4-methylcoumarin-7-yloxymethyl) phenyl]acrylate was discovered by using an intermediate derivatisation method. To discover new coumarin derivatives with improved activity, a series of substituted coumarins were synthesised and bioassayed. RESULTS: The compounds were identified by H-1 NMR, IR, MS and elemental analysis. Bioassays demonstrated that some of the title compounds exhibited excellent fungicidal activity against cucumber downy mildew at 25 mg L-1. The relationship between structure and fungicidal activity is reported. CONCLUSION: The present work demonstrates that coumarin derivatives containing methoxyacrylate moieties can be used as possible lead compounds for developing novel fungicides. (C) 2011 Society of Chemical Industry

引用

页码：647 / 655

页数：9

共 41 条

[1]

ALIOTTA G, 2000, CURR TOP PHYTOCHEM, V3, P167

[2] SYNTHESIS AND DERIVITIZATION OF 8-ACETYLPSORALENS - ACETYL MIGRATIONS DURING CLAISEN REARRANGEMENT [J].