Did the four human cancer cell lines DLD-1, HCT-15, HCT-8, and HRT-18 originate from one and the same patient?

被引：44

作者：

Vermeulen, SJ

Chen, TR

Speleman, F

Nollet, F

Van Roy, FM

Mareel, MM

机构：

[1] State Univ Ghent Hosp, Dept Radiotherapy & Nucl Med, Expt Cancerol Lab, B-9000 Ghent, Belgium

[2] Amer Type Culture Collect, Rockville, MD USA

[3] State Univ Ghent Hosp, Dept Med Genet, B-9000 Ghent, Belgium

[4] VIB, Mol Cell Biol Lab, Ghent, Belgium

[5] State Univ Ghent, B-9000 Ghent, Belgium

来源：

CANCER GENETICS AND CYTOGENETICS | 1998年 / 107卷 / 01期

关键词：

D O I：

10.1016/S0165-4608(98)00081-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Four human colon cancer cell lines, HCT-8, HRT-18, DLD-1, and HCT-15, with an epithelioid morphotype reproducibly formed alpha-catenin-deficient round cells. Using DNA fingerprinting, we found that these four cell lines have an identical genetic background. Our finding strongly suggests a genetic background for the reproducible loss of alpha-catenin and the ensuing acquisition of invasiveness in all four cell lines. (C) Elsevier Science Inc., 1998.

引用

页码：76 / 79

页数：4

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