Metastatic Pancreatic Neuroendocrine Tumor that Progressed to Ectopic Adrenocorticotropic Hormone (ACTH) Syndrome with Growth Hormone-releasing Hormone (GHRH) Production

被引：7

作者：

Tadokoro, Rie ^{[1
]}

Sato, Shotaro ^{[1
]}

Otsuka, Fumiko ^{[1
]}

Ueno, Makoto ^{[2
]}

Ohkawa, Shinichi ^{[2
]}

Katakami, Hideki ^{[3
]}

Taniyama, Matsuo ^{[1
]}

Nagasaka, Shoichiro ^{[1
]}

机构：

[1] Showa Univ, Dept Med, Div Diabet Metab & Endocrinol, Fujigaoka Hosp, Tokyo, Japan

[2] Kanagawa Canc Ctr, Div Hepatobiliary & Pancreat Med Oncol, Yokohama, Kanagawa, Japan

[3] Teikyo Univ, Div Clin Res Sci, Dept Med, Chiba Med Ctr, Tokyo, Japan

来源：

INTERNAL MEDICINE | 2016年 / 55卷 / 20期

关键词：

GHRH; ACTH; ectopic hormone secretion; PNET; CUSHINGS-SYNDROME; CARCINOID-TUMOR;

D O I：

10.2169/internalmedicine.55.6827

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The patient was a 61-year-old woman who had a well-differentiated pancreatic neuroendocrine tumor (PNET) with lymph node metastasis. After 15 months of octreotide treatment, glucose control deteriorated and pigmentation of the tongue and moon face developed, leading to the diagnosis of ectopic adrenocorticotropic hormone (ACTH) syndrome. An abnormal secretion of growth hormone (GH) was identified, and the plasma growth hormone-releasing hormone (GHRH) level was elevated. A tumor biopsy specimen positively immunostained for ACTH and GHRH. Ectopic hormone secretion seems to have evolved along with the progression of the PNET.

引用

页码：2979 / 2983

页数：5

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