SYNTHESIS AND ANTICANCER ACTIVITIES OF THIAZOLES, 1,3-THIAZINES, AND THIAZOLIDINE USING CHITOSAN-GRAFTEDPOLY(VINYLPYRIDINE) AS BASIC CATALYST

被引：312
作者：
Gomha, Sobhi M. [1 ]
Riyadh, Sayed M. [1 ,2 ]
Mahmmoud, Elmandi A. [1 ]
Elaasser, Mahmoud M. [3 ]
机构：
[1] Cairo Univ, Dept Chem, Fac Sci, Giza 12613, Egypt
[2] Taibah Univ, Fac Sci, Dept Chem, Almadinah 30002, Almunawrah, Saudi Arabia
[3] Al Azhar Univ, Reg Ctr Mycol & Biotechnol, Cairo, Egypt
来源：
HETEROCYCLES | 2015年 / 91卷 / 06期
关键词：
Thiazole; 1,3-Thiazine; Grafted-Chitosan; MM2; Calculation; Anticancer Activity; BIOLOGICAL EVALUATION; DERIVATIVES;
D O I：
10.3987/COM-15-13210
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Three different series of ethylidenehydrazonothiazoles 5a-c, 6a-c, ethylidenehydrazono-1,3-thiazines 9a-i and ethylidenehydrazonothiazolidine 12 have been prepared via reactions of ethylidenethiosemicarbazide 3a or ethylidenethiocarbohydrazide 3b with a-halocarbonyl compounds 4a-c, acrylonitrile derivatives 7a-i, and dimethyl acetylenedicarboxylate 10, respectively. Different basic catalysts were used in these reactions such as, triethylamine, chitosan, and chitosan-grafted-poly(vinylpyridine) and the latter catalyst has precedence as environmentally friendly basic catalyst. Moreover, the selected newly synthesized products were evaluated for their anti-cancer activity against a colon carcinoma cell line (HCT-116) and liver carcinoma cell line HEPG2 and revealed promising activity especially 1,3-thiazines 9c-i.
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页码：1227 / 1243
页数：17
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