c-Ski in health and disease

被引：71

作者：

Bonnon, Carine ^{[1
]}

Atanasoski, Suzana ^{[1
]}

机构：

[1] Univ Basel, Dept Biomed, Inst Physiol, CH-4056 Basel, Switzerland

来源：

CELL AND TISSUE RESEARCH | 2012年 / 347卷 / 01期

基金：

瑞士国家科学基金会;

关键词：

c-Ski; c-Ski-interacting partners; Signaling pathways; Cancer progression; Normal development; TRANSFORMING-GROWTH-FACTOR; SKELETAL-MUSCLE DIFFERENTIATION; PROMOTES TUMOR-GROWTH; SMAD PROTEINS; TRANSCRIPTIONAL REPRESSION; DROSOPHILA-DACHSHUND; ONCOPROTEIN SKI; DNA-BINDING; IN-VIVO; FIBROBLAST PROLIFERATION;

D O I：

10.1007/s00441-011-1180-z

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

c-Ski is an evolutionary conserved protein that is involved in diverse cellular processes such as proliferation, differentiation, transformation, and tumor progression. A large range of cellular partners of c-Ski, including transcription factors, chromatin-remodeling molecules, tumor suppressors, and nuclear hormone receptors, has been identified. Moreover, numerous mechanisms have been described by which c-Ski regulates essential signaling pathways, e.g., the TGF beta pathway. In this review, we summarize the diverse roles attributed to c-Ski during normal development and in cancer progression and discuss future strategies to unravel further the complex nature of c-Ski actions in a context-dependent manner.

引用

页码：51 / 64

页数：14

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