Age- and disease-specific reference values for neurofilament light presented in an online interactive support interface

被引：51

作者：

Vermunt, Lisa ^{[1
,2
]}

Otte, Marco ^{[3
]}

Verberk, Inge M. W. ^{[1
]}

Killestein, Joep ^{[4
]}

Lemstra, Afina W. ^{[2
]}

van der Flier, Wiesje M. ^{[2
,5
]}

Pijnenburg, Yolande A. L. ^{[2
]}

Vijverberg, Everard G. B. ^{[2
]}

Bouwman, Femke H. ^{[2
]}

Gravesteijn, Gido ^{[6
,7
]}

van de Berg, Wilma D. J. ^{[8
]}

Scheltens, Philip ^{[2
,9
]}

van Harten, Argonde C. ^{[2
]}

Willemse, Eline A. J. ^{[1
]}

Teunissen, Charlotte E. ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Dept Clin Chem, Neurochem Lab, Amsterdam UMC,Amsterdam Neurosci, Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam UMC,Amsterdam Neurosci, Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Network Inst, Amsterdam, Netherlands

[4] Vrije Univ Amsterdam, MS Ctr Amsterdam, Dept Neurol, Amsterdam UMC,Amsterdam Neurosci, Amsterdam, Netherlands

[5] Vrije Univ Amsterdam, Dept Epidemiol & Data Sci, Amsterdam UMC, Amsterdam, Netherlands

[6] Leiden Univ, Dept Clin Genet, Med Ctr, Leiden, Netherlands

[7] Leiden Univ, Dept Human Genet, Med Ctr, Leiden, Netherlands

[8] Vrije Univ Amsterdam, Dept Anat & Neurosci, Amsterdam UMC, Amsterdam Neurosci,Clin Neuroanat & Biobanking, Amsterdam, Netherlands

[9] Life Sci Partners LSP, Amsterdam, Netherlands

来源：

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | 2022年 / 9卷 / 11期

关键词：

DEMENTIA; CHAIN;

D O I：

10.1002/acn3.51676

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Interpretation of axonal damage biomarker Neurofilament Light chain (NfL) concentrations is difficult due to the lack of age-specific and disease-specific reference values. We here developed an interactive interface to support interpretation of NfL results in human body fluids. We used NfL values of 1698 individuals without a neurological disorder, aged 19-85 years, and patients with MS and dementias. Percentile regression estimates per diagnosis populate interactive graphs, alongside NfL background information (available on: https:// mybiomarkers.shinyapps.io/Neurofilament). This accessible interface provides reference for interpretation of the individual patient results for clinicians. It showcases an adaptable method to support interpretation of age-dependent biomarkers in neurology.

引用

页码：1832 / 1837

页数：6

共 22 条

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