Carbohydrate-based templates for synthetic vaccines and drug delivery

被引：31

作者：

McGeary, RP

Jablonkai, I

Toth, I

机构：

[1] Univ Queensland, Sch Pharm, Brisbane, Qld 4072, Australia

[2] Alchemia Pty Ltd, Hi Tech Court 3, Brisbane, Qld 4113, Australia

[3] Univ London, Sch Pharm, Dept Pharmaceut & Biol Sci, London W1CN 1AX, England

[4] Hungarian Acad Sci, Chem Res Ctr, Inst Chem, H-1025 Budapest, Hungary

来源：

TETRAHEDRON | 2001年 / 57卷 / 41期

基金：

英国惠康基金;

关键词：

synthetic vaccines; carbohydrates; solid-phase synthesis; adjuvants/carriers;

D O I：

10.1016/S0040-4020(01)00852-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Methyl tetra-O-allyl, and tetra-O-[2-(tetrahydro-2H-pyranyl)oxy.-3-oxapentyl glucosides, and tetra-O-(cyanoethyl)galactosyl azide were converted into derivatives containing linkers with terminal carboxylic acid functionalities at the anomeric position and bearing four arms with phthaloyl- or BOC-protected terminal amino groups. These molecules were suitable for use in solid-phase peptide synthesis and for the preparation of dendrimers, containing multiple copies of peptides. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：8733 / 8742

页数：10

共 15 条

[1] HYDROLYSIS OF CYANOETHYLATED CARBOHYDRATES - SYNTHESIS OF NEW CARBOXYLIC DERIVATIVES OF SUCROSE, D-GLUCOSE AND D-FRUCTOSE [J].