High performance of magnetic mesoporous modification for loading and release of meloxicam in drug delivery implementation

In this work, a sol-gel technique was applied to synthesize mesoporous silica (MPSS) SBA-15 and modify it to magnetic mesoporous (MMPS) Fe3O4/SBA-15. The surface engineering modification was implemented according to the incipient wetness impregnation (IWI) method to create specific magnetic sites adsorbent for loading and release of Meloxicam (MEL). The MPSS and MMPS were characterized by X-ray diffraction (XRD), scanning electron microscope (SEM), Fourier transform infrared (FT-IR), BET surface area, and thermal gravimetric analysis (TGA). Four parameters were investigated: pH, concentration of drug, dose of carriers, and contact time. The maximum drug loading efficiencies (DL%) on SBA-15 and Fe3O4/SBA-15were 31.81 % and 42.85 % respectively. The MEL released was studied in phosphate buffer solution (PBS) at pH 7.4. The release of MEL from SBA-15 and Fe3O4/SBA-15 after 18 and 24 h was 85.76 % and 78.13 % respectively. Freundlich adsorption isotherm was the most acceptable for the two carrier's SBA-15 and Fe3O4/SBA-15. The kinetics models for the drugs release fitted well with the first order kinetic model. The drug loading process was investigated in a batch system by implementation of experimental design technique. The objective function (response) was the drug loading efficiency (DL%). A response surface method (RSM) was applied to define the optimum and significant factors that affect the drug loading process.