Natural Alkaloids and Heterocycles as G-Quadruplex Ligands and Potential Anticancer Agents

被引：48

作者：

Che, Tong ^{[1
]}

Wang, Yu-Qing ^{[1
]}

Huang, Zhou-Li ^{[1
]}

Tan, Jia-Heng ^{[1
]}

Huang, Zhi-Shu ^{[1
]}

Chen, Shuo-Bin ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

来源：

MOLECULES | 2018年 / 23卷 / 02期

基金：

中国国家自然科学基金;

关键词：

natural alkaloids; anticancer agents; drug design; G-quadruplex; TELOMERIC G-QUADRUPLEX; C-MYC TRANSCRIPTION; INTRAMOLECULAR G-QUADRUPLEX; HIGHLY SELECTIVE LIGANDS; LIGHT-UP PROBE; NUCLEASE HYPERSENSITIVE ELEMENT; PARALLEL G-QUADRUPLEXES; QUINDOLINE DERIVATIVES; STABILIZING LIGANDS; ISAINDIGOTONE DERIVATIVES;

D O I：

10.3390/molecules23020493

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

G-quadruplexes are four-stranded nucleic acid secondary structures that are formed in guanine-rich sequences. G-quadruplexes are widely distributed in functional regions of the human genome and transcriptome, such as human telomeres, oncogene promoter regions, replication initiation sites, and untranslated regions. Many G-quadruplex-forming sequences are found to be associated with cancer, and thus, these non-canonical nucleic acid structures are considered to be attractive molecular targets for cancer therapeutics with novel mechanisms of action. In this mini review, we summarize recent advances made by our lab in the study of G-quadruplex-targeted natural alkaloids and their derivatives toward the development of potential anticancer agents.

引用

页数：19