Natural Alkaloids and Heterocycles as G-Quadruplex Ligands and Potential Anticancer Agents
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作者:
Che, Tong
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Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
Che, Tong
[1
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Wang, Yu-Qing
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Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
Wang, Yu-Qing
[1
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Huang, Zhou-Li
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Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
Huang, Zhou-Li
[1
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Tan, Jia-Heng
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Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
Tan, Jia-Heng
[1
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Huang, Zhi-Shu
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Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
Huang, Zhi-Shu
[1
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Chen, Shuo-Bin
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Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
Chen, Shuo-Bin
[1
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机构:
[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
G-quadruplexes are four-stranded nucleic acid secondary structures that are formed in guanine-rich sequences. G-quadruplexes are widely distributed in functional regions of the human genome and transcriptome, such as human telomeres, oncogene promoter regions, replication initiation sites, and untranslated regions. Many G-quadruplex-forming sequences are found to be associated with cancer, and thus, these non-canonical nucleic acid structures are considered to be attractive molecular targets for cancer therapeutics with novel mechanisms of action. In this mini review, we summarize recent advances made by our lab in the study of G-quadruplex-targeted natural alkaloids and their derivatives toward the development of potential anticancer agents.
机构:
Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510080, Guangdong, Peoples R China
Tan, Jia-Heng
Gu, Lian-Quan
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Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510080, Guangdong, Peoples R China
Gu, Lian-Quan
Wu, Jian-Yong
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Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
Hong Kong Polytech Univ, State Key Lab Chinese Med & Mol Pharmacol, Kowloon, Hong Kong, Peoples R ChinaSun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510080, Guangdong, Peoples R China
机构:
Cent Univ Las Villas, Dept Pharm, Santa Clara 54830, Villa Clara, Cuba
Cent Univ Las Villas, Ctr Chem Bioact, Mol Simulat & Drug Design Grp, Santa Clara 54830, Villa Clara, Cuba
Univ Bordeaux, ARNA Lab, IECB, F-33600 Pessac, France
INSERM, U869, ARNA Lab, F-33000 Bordeaux, FranceCent Univ Las Villas, Dept Pharm, Santa Clara 54830, Villa Clara, Cuba
Castillo-Gonzalez, Daimel
Perez-Machado, Gisselle
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Cent Univ Las Villas, Dept Pharm, Santa Clara 54830, Villa Clara, Cuba
Cent Univ Las Villas, Ctr Chem Bioact, Mol Simulat & Drug Design Grp, Santa Clara 54830, Villa Clara, Cuba
Univ Valencia, Fac Med, Dept Physiol, E-46003 Valencia, SpainCent Univ Las Villas, Dept Pharm, Santa Clara 54830, Villa Clara, Cuba
Perez-Machado, Gisselle
Pallardo, Federico
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Univ Valencia, Fac Med, Dept Physiol, E-46003 Valencia, SpainCent Univ Las Villas, Dept Pharm, Santa Clara 54830, Villa Clara, Cuba
Pallardo, Federico
Garrigues-Pelufo, Teresa-Maria
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Univ Valencia, Fac Pharm, Dept Pharm & Pharmaceut Technol, E-46100 Burjassot, SpainCent Univ Las Villas, Dept Pharm, Santa Clara 54830, Villa Clara, Cuba
Garrigues-Pelufo, Teresa-Maria
Cabrera-Perez, Miguel-Angel
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Cent Univ Las Villas, Ctr Chem Bioact, Mol Simulat & Drug Design Grp, Santa Clara 54830, Villa Clara, Cuba
Univ Valencia, Fac Pharm, Dept Pharm & Pharmaceut Technol, E-46100 Burjassot, SpainCent Univ Las Villas, Dept Pharm, Santa Clara 54830, Villa Clara, Cuba
机构:
Fdn IRCCS Ist Nazl Tumori Milano, Dept Appl Res & Technol Dev, Mol Pharmacol Unit, Via GA Amadeo 42, I-20133 Milan, ItalyFdn IRCCS Ist Nazl Tumori Milano, Dept Appl Res & Technol Dev, Mol Pharmacol Unit, Via GA Amadeo 42, I-20133 Milan, Italy
Alessandrini, Irene
Recagni, Marta
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Fdn IRCCS Ist Nazl Tumori Milano, Dept Appl Res & Technol Dev, Mol Pharmacol Unit, Via GA Amadeo 42, I-20133 Milan, ItalyFdn IRCCS Ist Nazl Tumori Milano, Dept Appl Res & Technol Dev, Mol Pharmacol Unit, Via GA Amadeo 42, I-20133 Milan, Italy
Recagni, Marta
Zaffaroni, Nadia
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Fdn IRCCS Ist Nazl Tumori Milano, Dept Appl Res & Technol Dev, Mol Pharmacol Unit, Via GA Amadeo 42, I-20133 Milan, ItalyFdn IRCCS Ist Nazl Tumori Milano, Dept Appl Res & Technol Dev, Mol Pharmacol Unit, Via GA Amadeo 42, I-20133 Milan, Italy
Zaffaroni, Nadia
Folini, Marco
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Fdn IRCCS Ist Nazl Tumori Milano, Dept Appl Res & Technol Dev, Mol Pharmacol Unit, Via GA Amadeo 42, I-20133 Milan, ItalyFdn IRCCS Ist Nazl Tumori Milano, Dept Appl Res & Technol Dev, Mol Pharmacol Unit, Via GA Amadeo 42, I-20133 Milan, Italy