Regulation of Differentiation of Mesenchymal Stem Cells into Musculoskeletal Cells

被引：25
|
作者：
Thanabalasundaram, Gopiga [1 ]
Arumalla, Nikita [1 ]
Tailor, Hiteshkumar D. [1 ]
Khan, Wasim S. [1 ]
机构：
[1] UCL, Sch Med, London WC1E 6BT, England
来源：
CURRENT STEM CELL RESEARCH & THERAPY | 2012年 / 7卷 / 02期
关键词：
Adipocytes; chondrocytes; differentiation; mesenchymal stem cells; myocytes; osteoblasts; tenocytes; BONE MORPHOGENETIC PROTEIN-2; SKELETAL-MUSCLE DIFFERENTIATION; SHOW ENHANCED CHONDROGENESIS; LAR TYROSINE PHOSPHATASE; EPIDERMAL-GROWTH-FACTOR; INFRAPATELLAR FAT PAD; MARROW STROMAL CELLS; PERICYTE MARKER 3G5; OSTEOGENIC DIFFERENTIATION; IN-VITRO;
D O I：
10.2174/157488812799218974
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Mesenchymal stem cells (MSCs) are multipotent cells that have the capability of differentiating into several different cells such as osteoblasts (bone), chondrocytes (cartilage), adipocytes (fat), myocytes (muscle) and tenocytes (tendon). In this review we highlight the different regulators which determine the lineage a particular MSC will differentiate into. Mesenchymal stem cells are increasingly being used in tissue regeneration and repair. Strict regulation of differentiation of MSCs is essential for a positive outcome of the particular tissue treated with MSCs, especially due to the fact that capacity to differentiate decreases with increasing age of the donor.
引用
收藏
页码：95 / 102
页数：8
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