Vitamin K Supplementation for Prevention of Vascular Calcification in Chronic Kidney Disease Patients: Are We There Yet?

被引：26

作者：

Roumeliotis, Stefanos ^{[1
]}

Duni, Anila ^{[2
]}

Vaios, Vasilios ^{[1
]}

Kitsos, Athanasios ^{[2
]}

Liakopoulos, Vassilios ^{[1
]}

Dounousi, Evangelia ^{[2
]}

机构：

[1] Aristotle Univ Thessaloniki, Div Nephrol & Hypertens, Sch Med, AHEPA Hosp,Dept Internal Med 1, Thessaloniki 54636, Greece

[2] Univ Ioannina, Fac Med, Sch Hlth Sci, Dept Nephrol, Ioannina 45110, Greece

来源：

NUTRIENTS | 2022年 / 14卷 / 05期

关键词：

cardiovascular disease; chronic kidney disease; end-stage kidney disease; hemodialysis; Matrix Gla Protein; menaquinone-7; vascular calcification; vitamin K; MATRIX-GLA-PROTEIN; BONE MORPHOGENETIC PROTEIN-2; INTIMA-MEDIA THICKNESS; STAGE RENAL-DISEASE; ALL-CAUSE MORTALITY; HEMODIALYSIS-PATIENTS; CARDIOVASCULAR-DISEASE; CARDIAC CALCIFICATION; POTENTIAL MECHANISM; GENE POLYMORPHISMS;

D O I：

10.3390/nu14050925

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Chronic Kidney Disease (CKD) patients are at high risk of presenting with arterial calcification or stiffness, which confers increased cardiovascular mortality and morbidity. In recent years, it has become evident that VC is an active process regulated by various molecules that may act as inhibitors of vessel mineralization. Matrix Gla Protein (MGP), one the most powerful naturally occurring inhibitors of arterial calcification, requires vitamin K as a co-factor in order to undergo post-translational gamma-carboxylation and phosphrorylation and become biologically active. The inactive form of MGP (dephosphorylated, uncarboxylated dp-ucMGP) reflects vitamin K deficiency and has been repeatedly associated with surrogate markers of VC, stiffness, and cardiovascular outcomes in CKD populations. As CKD is a state of progressive vitamin K depletion and VC, research has focused on clinical trials aiming to investigate the possible beneficial effects of vitamin K in CKD and dialysis patients. In this study, we aim to review the current evidence regarding vitamin K supplementation in uremic patients.

引用

页数：14

共 103 条

[1] High Dephosphorylated-Uncarboxylated MGP in Hemodialysis patients: risk factors and response to vitamin K2, A pre-post intervention clinical trial [J].