Concurrent hypopituitarism and leukemic retinopathy in a child with B-precursor acute lymphoblastic leukemia and isolated central nervous system relapse

被引：0

作者：

Wu, K. H. ^{[1
,2
]}

Wu, H. P. ^{[3
,4
]}

Lin, H. J. ^{[5
,6
]}

Wang, C. H. ^{[1
,7
]}

Chen, H. Y. ^{[8
]}

Weng, T. ^{[2
]}

Peng, C. T. ^{[2
,9
]}

Chao, Y. H. ^{[10
,11
]}

机构：

[1] China Med Univ, Coll Chinese Med, Sch Post Baccalaureate Chinese Med, Taichung, Taiwan

[2] China Med Univ, Childrens Hosp, Div Pediat Hematol Oncol, Taichung, Taiwan

[3] Chang Gung Mem Hosp, Dept Pediat, Div Pediat Gen Med, Taoyuan, Taiwan

[4] Chang Gung Univ, Coll Med, Taoyuan, Taiwan

[5] China Med Univ Hosp, Dept Ophthalmol, Taichung, Taiwan

[6] China Med Univ Hosp, Dept Med Res, Taichung, Taiwan

[7] China Med Univ, Childrens Hosp, Div Genet & Metab, Taichung, Taiwan

[8] China Med Univ Hosp, Dept Radiol, Taichung, Taiwan

[9] Asia Univ, Dept Biotechnol & Bioinformat, Taichung, Taiwan

[10] Chung Shan Med Univ Hosp, Dept Pediat, Taichung, Taiwan

[11] Chung Shan Med Univ, Sch Med, Taichung, Taiwan

来源：

CURRENT ONCOLOGY | 2016年 / 23卷 / 04期

关键词：

Hypopituitarism; retinopathy; acute lymphoblastic leukemia; central nervous system relapse; MESENCHYMAL STEM-CELLS; ACUTE MYELOID-LEUKEMIA; GROWTH-HORMONE; RADIATION; INVOLVEMENT; AUTOPSY; EYE;

D O I：

10.3747/co.23.3006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hypopituitarism in leukemia is very rare. In addition, central nervous system (CNS) relapse and leukemic retinopathy in childhood acute lymphoblastic leukemia (ALL) have declined with the use of modern systemic chemotherapy that includes CNS prophylaxis. Here, we report the case of a 4-year-old girl who received chemotherapy and intrathecal therapy without CNS radiation after a diagnosis of B-precursor ALL without CNS involvement. Three months after chemotherapy completion, she presented with lower-extremity weakness and was diagnosed with an isolated CNS relapse. Concurrent hypopituitarism and leukemic retinopathy were also found. After receiving craniospinal radiotherapy and systemic chemotherapy, her retinopathy and vision improved. She is now in complete remission, and she is still on chemotherapy according to the guideline from the Pediatric Oncology Group. Although rare, hypopituitarism and leukemic retinopathy should be taken into consideration in patients with CNS involvement by leukemia.

引用

页码：E431 / E434

页数：4