Facile syntheses of substituted 2,3-dihydrofurans and benzofurans by palladium-catalyzed reactions of propargylic carbonates with nucleophiles

被引：47

作者：

Yoshida, M ^{[1
]}

Morishita, Y ^{[1
]}

Fujita, M ^{[1
]}

Ihara, M ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Dept Organ Chem, Sendai, Miyagi 9808578, Japan

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 09期

基金：

日本学术振兴会;

关键词：

palladium; cyclization; dihydrofurans; phenols;

D O I：

10.1016/j.tetlet.2004.01.012

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Substituted 2,3-dihydrofurans and benzofurans are synthesized by the palladium-catalyzed reaction of 5-methoxycarbonytoxy-3-pentyn-1-ols and 1-(2-hydroxyphenyl)-3-methoxycarbonyloxy-1-propyne with nucleophiles, respectively. Various substituted propargylic carbonates and nucleophiles are efficiently transformed to their corresponding products. Additionally, a reaction using substrates containing a nucleophilic phenoxy group within the same molecule also produces the corresponding dihydrofuran. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1861 / 1864

页数：4

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