Versatile T1-Based Chemical Analysis Platform Using Fe3+/Fe2+ Interconversion

被引：35

作者：

Chen, Yiping ^{[1
,2
]}

Yin, Binfeng ^{[1
,2
]}

Dong, Mingling ^{[1
,2
]}

Xianyu, Yunlei ^{[1
,2
]}

Jiang, Xingyu ^{[1
,2
,3
]}

机构：

[1] Beijing Engn Res Ctr BioNanotechnol, 11 Beiyitiao, Beijing 100190, Peoples R China

[2] Natl Ctr NanoSci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biol Effects Nanomat & Nanosafety, 11 Beiyitiao, Beijing 100190, Peoples R China

[3] Univ Chinese Acad Sci, 19 A YuQuan Rd, Beijing 100049, Peoples R China

来源：

ANALYTICAL CHEMISTRY | 2018年 / 90卷 / 02期

基金：

美国国家科学基金会;

关键词：

ULTRASENSITIVE DETECTION; ONE-STEP; NANOPARTICLES; RELAXATION; CHEMISTRY; PATHOGENS; MICRORNA; CONTRAST; ALLOWS; AGENTS;

D O I：

10.1021/acs.analchem.7b03961

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We report a versatile analytical platform for assaying multiple analytes relying on changes in longitudinal relaxation time (T-1) as a result of Fe3+/Fe2+ interconversion. The T-1 of water protons in Fe3+ aqueous solution differs significantly from that of Fe2+, allowing for the development of a generally applicable Trbased assay since many redox reactions enable the interconversion between Fe' and Fe3+ that can result in the change of Ti. Compared with conventional magnetic biosensors, this T-1-based assay is free of magnetic nanoparticles (MNPs), and the stability of T-1 based assay is better than conventional magnetic sensors that suffer from nonspecific adsorption and aggregation of MNPs. This T-1-based assay simultaneously enables "one-step mixing" assays (such as saliva sugar) and "multiple-washing" immunoassays with good stability and sensitivity, offering a promising platform for convenient, stable, and versatile biomedical analysis

引用

页码：1234 / 1240

页数：7

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