Versatile T1-Based Chemical Analysis Platform Using Fe3+/Fe2+ Interconversion

被引：35
作者：
Chen, Yiping [1 ,2 ]
Yin, Binfeng [1 ,2 ]
Dong, Mingling [1 ,2 ]
Xianyu, Yunlei [1 ,2 ]
Jiang, Xingyu [1 ,2 ,3 ]
机构：
[1] Beijing Engn Res Ctr BioNanotechnol, 11 Beiyitiao, Beijing 100190, Peoples R China
[2] Natl Ctr NanoSci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biol Effects Nanomat & Nanosafety, 11 Beiyitiao, Beijing 100190, Peoples R China
[3] Univ Chinese Acad Sci, 19 A YuQuan Rd, Beijing 100049, Peoples R China
来源：
ANALYTICAL CHEMISTRY | 2018年 / 90卷 / 02期
基金：
美国国家科学基金会;
关键词：
ULTRASENSITIVE DETECTION; ONE-STEP; NANOPARTICLES; RELAXATION; CHEMISTRY; PATHOGENS; MICRORNA; CONTRAST; ALLOWS; AGENTS;
D O I：
10.1021/acs.analchem.7b03961
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
We report a versatile analytical platform for assaying multiple analytes relying on changes in longitudinal relaxation time (T-1) as a result of Fe3+/Fe2+ interconversion. The T-1 of water protons in Fe3+ aqueous solution differs significantly from that of Fe2+, allowing for the development of a generally applicable Trbased assay since many redox reactions enable the interconversion between Fe' and Fe3+ that can result in the change of Ti. Compared with conventional magnetic biosensors, this T-1-based assay is free of magnetic nanoparticles (MNPs), and the stability of T-1 based assay is better than conventional magnetic sensors that suffer from nonspecific adsorption and aggregation of MNPs. This T-1-based assay simultaneously enables "one-step mixing" assays (such as saliva sugar) and "multiple-washing" immunoassays with good stability and sensitivity, offering a promising platform for convenient, stable, and versatile biomedical analysis
引用
收藏
页码：1234 / 1240
页数：7
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