Versatile T1-Based Chemical Analysis Platform Using Fe3+/Fe2+ Interconversion

被引：38
作者：
Chen, Yiping [1 ,2 ]
Yin, Binfeng [1 ,2 ]
Dong, Mingling [1 ,2 ]
Xianyu, Yunlei [1 ,2 ]
Jiang, Xingyu [1 ,2 ,3 ]
机构：
[1] Beijing Engn Res Ctr BioNanotechnol, 11 Beiyitiao, Beijing 100190, Peoples R China
[2] Natl Ctr NanoSci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biol Effects Nanomat & Nanosafety, 11 Beiyitiao, Beijing 100190, Peoples R China
[3] Univ Chinese Acad Sci, 19 A YuQuan Rd, Beijing 100049, Peoples R China
来源：
ANALYTICAL CHEMISTRY | 2018年 / 90卷 / 02期
基金：
美国国家科学基金会;
关键词：
ULTRASENSITIVE DETECTION; ONE-STEP; NANOPARTICLES; RELAXATION; CHEMISTRY; PATHOGENS; MICRORNA; CONTRAST; ALLOWS; AGENTS;
D O I：
10.1021/acs.analchem.7b03961
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
We report a versatile analytical platform for assaying multiple analytes relying on changes in longitudinal relaxation time (T-1) as a result of Fe3+/Fe2+ interconversion. The T-1 of water protons in Fe3+ aqueous solution differs significantly from that of Fe2+, allowing for the development of a generally applicable Trbased assay since many redox reactions enable the interconversion between Fe' and Fe3+ that can result in the change of Ti. Compared with conventional magnetic biosensors, this T-1-based assay is free of magnetic nanoparticles (MNPs), and the stability of T-1 based assay is better than conventional magnetic sensors that suffer from nonspecific adsorption and aggregation of MNPs. This T-1-based assay simultaneously enables "one-step mixing" assays (such as saliva sugar) and "multiple-washing" immunoassays with good stability and sensitivity, offering a promising platform for convenient, stable, and versatile biomedical analysis
引用
收藏
页码：1234 / 1240
页数：7
相关论文
共 42 条
[1]   Serial serum alkaline phosphatase as an early biomarker for osteopenia of prematurity [J].
Abdallah, Enas A. A. ;
Said, Reem N. ;
Mosallam, Dalia S. ;
Moawad, Eman M. I. ;
Kamal, Naglaa M. ;
Fathallah, Mohammed G. E-D. .
MEDICINE, 2016, 95 (37)
[2]   Biotechnological approaches toward nanoparticle biofunctionalization [J].
Avvakumova, Svetlana ;
Colombo, Miriam ;
Tortora, Paolo ;
Prosperi, Davide .
TRENDS IN BIOTECHNOLOGY, 2014, 32 (01) :11-20
[3]   The stabilization and bio-functionalization of iron oxide nanoparticles using heterotelechelic polymers [J].
Boyer, Cyrille ;
Bulmus, Volga ;
Priyanto, Priyanto ;
Teoh, Wey Yang ;
Amal, Rose ;
Davis, Thomas P. .
JOURNAL OF MATERIALS CHEMISTRY, 2009, 19 (01) :111-123
[4]   Surface Modification of Gold Nanoparticles with Small Molecules for Biochemical Analysis [J].
Chen, Yiping ;
Xianyu, Yunlei ;
Jiang, Xingyu .
ACCOUNTS OF CHEMICAL RESEARCH, 2017, 50 (02) :310-319
[5]   A dual-readout chemiluminescent-gold lateral flow test for multiplex and ultrasensitive detection of disease biomarkers in real samples [J].
Chen, Yiping ;
Sun, Jiashu ;
Xianyu, Yunlei ;
Yin, Binfeng ;
Niu, Yajing ;
Wang, Songbai ;
Cao, Fengjing ;
Zhang, Xiaoqing ;
Wang, Yu ;
Jiang, Xingyu .
NANOSCALE, 2016, 8 (33) :15205-15212
[6]   Click Chemistry-Mediated Nanosensors for Biochemical Assays [J].
Chen, Yiping ;
Xianyu, Yunlei ;
Wu, Jing ;
Yin, Binfeng ;
Jiang, Xingyu .
THERANOSTICS, 2016, 6 (07) :969-985
[7]   One-Step Detection of Pathogens and Viruses: Combining Magnetic Relaxation Switching and Magnetic Separation [J].
Chen, Yiping ;
Xianyu, Yunlei ;
Wang, Yu ;
Zhang, Xiaoqing ;
Cha, Ruitao ;
Sun, Jiashu ;
Jiang, Xingyu .
ACS NANO, 2015, 9 (03) :3184-3191
[8]  
Choi JS, 2017, NAT MATER, V16, P537, DOI [10.1038/nmat4846, 10.1038/NMAT4846]
[9]  
Chung HJ, 2013, NAT NANOTECHNOL, V8, P369, DOI [10.1038/NNANO.2013.70, 10.1038/nnano.2013.70]
[10]   Magnetic resonance for in vitro medical diagnostics: superparamagnetic nanoparticle-based magnetic relaxation switches [J].
Demas, Vasiliki ;
Lowery, Thomas J. .
NEW JOURNAL OF PHYSICS, 2011, 13
12345