5-Alpha reductase inhibitors in androgenetic alopecia: Shifting paradigms, current concepts, comparative efficacy, and safety

被引：51

作者：

Dhurat, Rachita ^{[1
]}

Sharma, Aseem ^{[2
]}

Rudnicka, Lidia ^{[3
]}

Kroumpouzos, George ^{[4
,5
,6
]}

Kassir, Martin ^{[7
]}

Galadari, Hassan ^{[8
]}

Wollina, Uwe ^{[9
]}

Lotti, Torello ^{[10
]}

Golubovic, Masa ^{[11
]}

Binic, Iva ^{[12
]}

Grabbe, Stephan ^{[13
]}

Goldust, Mohamad ^{[14
,15
,16
]}

机构：

[1] LTMMC & LTMGH, Dept Dermatol, Mumbai, Maharashtra, India

[2] Sion Hosp, LTMMC & LTMGH, Dept Dermatol, Mumbai, Maharashtra, India

[3] Med Univ Warsaw, Dept Dermatol, Warsaw, Poland

[4] Brown Univ, Alpert Med Sch, Dept Dermatol, Providence, RI 02912 USA

[5] Med Sch Jundiai, Dept Dermatol, Sao Paulo, Brazil

[6] GK Dermatol PC, South Weymouth, MA USA

[7] Worldwide Laser Inst, Dallas, TX USA

[8] United Arab Emirates Univ, Coll Med & Hlth Sci, Al Ain, U Arab Emirates

[9] Tech Univ Dresden, Acad Teaching Hosp, Stadt Klinikum Dresden, Dept Dermatol & Allergol, Dresden, Germany

[10] Univ Studies Guglielmo Marconi, Rome, Italy

[11] Clin Ctr Nis, Clin Dermatovenerol, Nish, Serbia

[12] Clin Ctr Nis, Psychiat Clin, Nish, Serbia

[13] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Dermatol, Mainz, Germany

[14] Univ Rome G Marconi, Rome, Italy

[15] Univ Med Ctr Mainz, Dept Dermatol, Mainz, Germany

[16] Univ Hosp Basel, Dept Dermatol, Basel, Switzerland

来源：

DERMATOLOGIC THERAPY | 2020年 / 33卷 / 03期

关键词：

5-alpha reductase inhibitors; androgenetic alopecia; dutasteride; finasteride; DUTASTERIDE; FINASTERIDE; 5-ALPHA-REDUCTASE; MEN; METABOLISM; PLACEBO; SIDE; MG;

D O I：

10.1111/dth.13379

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Androgenetic alopecia (AGA) is a multifactorial disease that carries a significant psychological burden with it. Dihydrotestosterone, the main pathogenic androgen in AGA, is produced by conversion of testosterone, which is catalyzed by the 5-alpha reductase (5-AR) isoenzyme family. Finasteride and dutasteride are inhibitors of these enzymes. Finasteride, which is a single receptor 5-alpha reductase inhibitor (5-ARI), acts by blocking dihydrotestosterone (DHT). Dutasteride, a dual receptor DHT blocker, has a higher potency than its predecessor, finasteride. This review corroborates the evidence of superiority of dutasteride over finasteride, and its comparable safety profile concerning fertility, teratogenicity, neurotoxicity, and hepatotoxicity.

引用

页数：5

共 38 条

[1] Finasteride use during pregnancy and early neonatal outcome: a case report [J].

AlSaad, Doua ;

Lee, Ben H. ;

Al-Obaidly, Sawsan .

INTERNATIONAL JOURNAL OF CLINICAL PHARMACY, 2018, 40 (04) :803-805

[2] The effect of 5α reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men [J].

Amory, John K. ;

Wang, Christina ;

Swerdloff, Ronald S. ;

Anawalt, Bradley D. ;

Matsumoto, Alvin M. ;

Bremner, William J. ;

Walker, Susan E. ;

Haberer, Lynda J. ;

Clark, Richard V. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (05) :1659-1665

[3] Effect of Dutasteride on the Risk of Prostate Cancer. [J].

Andriole, Gerald L. ;

Bostwick, David G. ;

Brawley, Otis W. ;

Gomella, Leonard G. ;

Marberger, Michael ;

Montorsi, Francesco ;

Pettaway, Curtis A. ;

Tammela, Teuvo L. ;

Teloken, Claudio ;

Tindall, Donald J. ;

Somerville, Matthew C. ;

Wilson, Timothy H. ;

Fowler, Ivy L. ;

Rittmaster, Roger S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 362 (13) :1192-1202

[4] Controversies in the treatment of androgenetic alopecia: The history of finasteride [J].

Andy, Goren ;

John, McCoy ;

Mirna, Situm ;

Rachita, Dhurat ;

Michael, Krychman ;

Maja, Kovacevic ;

Aseem, Sharma ;

Zeljana, Bolanca .

DERMATOLOGIC THERAPY, 2019, 32 (02)

[5] Effects of in utero exposure to finasteride on androgen-dependent reproductive development in the male rat [J].

Bowman, CJ ;

Barlow, NJ ;

Turner, KJ ;

Wallace, DG ;

Foster, PMD .

TOXICOLOGICAL SCIENCES, 2003, 74 (02) :393-406

[6] A liposome-based formulation containing equol, dihomo-γ-linolenic acid and propionyl-l-carnitine to prevent and treat hair loss: A prospective investigation [J].

Brotzu, Giovanni ;

Fadda, Anna Maria ;

Manca, Maria Letizia ;

Manca, Thomas ;

Marongiu, Francesca ;

Campisi, Monica ;

Consolaro, Francesca .

DERMATOLOGIC THERAPY, 2019, 32 (01)

[7] Cutaneous androgen metabolism: Basic research and clinical perspectives [J].

Chen, WC ;

Thiboutot, D ;

Zouboulis, CC .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2002, 119 (05) :992-1007

[8] Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5α-reductase inhibitor [J].

Clark, RV ;

Hermann, DJ ;

Cunningham, GR ;

Wilson, TH ;

Morrill, BB ;

Hobbs, S .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (05) :2179-2184

[9] Efficacy and safety of long-term treatment with the dual 5α-reductase inhibitor dutasteride in men with symptomatic benign prostatic hyperplasia [J].

Debruyne, F ;

Barkin, J ;

van Erps, P ;

Reis, M ;

Tammela, TLJ ;

Roehrborn, C .

EUROPEAN UROLOGY, 2004, 46 (04) :488-495

[10] Topical ketoconazole for the treatment of androgenetic alopecia: A systematic review [J].

Fields, Jaime R. ;

Vonu, Peter M. ;

Monir, Reesa L. ;

Schoch, Jennifer J. .

DERMATOLOGIC THERAPY, 2020, 33 (01)

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