Human 8-cell-like cells discovered

被引：2

作者：

Balaton, Bradley P. ^{[1
]}

Pasque, Vincent ^{[1
]}

机构：

[1] KU Leuven Univ Leuven, Dept Dev & Regenerat, Leuven Inst Single Cell Omics LISCO, Leuven Stem Cell Inst, Leuven, Belgium

来源：

CELL STEM CELL | 2022年 / 29卷 / 03期

关键词：

D O I：

10.1016/j.stem.2022.01.015

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Human naive pluripotent stem cells have the remarkable ability to generate blastoids comprising trophecto-derm, epiblast, and hypoblast-like cells. In this issue, Taubenschmid-Stowers et al. (2022) show that human naive pluripotent stem cell cultures contain cells that resemble the 8-cell human embryo, providing a model to study zygotic genome activation.

引用

页码：347 / 348

页数：2

共 9 条

[1] Human embryonic genome activation initiates at the one-cell stage [J].

Asami, Maki ;

Lam, Brian Y. H. ;

Ma, Marcella K. ;

Rainbow, Kara ;

Braun, Stefanie ;

VerMilyea, Matthew D. ;

Yeo, Giles S. H. ;

Perry, Anthony C. F. .

CELL STEM CELL, 2022, 29 (02) :209-+

[2] Defining the three cell lineages of the human blastocyst by single-cell RNA-seq (vol 142, pg 3151, 2015) [J].

Blakeley, Paul ;

Fogarty, Norah M. E. ;

del Valle, Ignacio ;

Wamaitha, Sissy E. ;

Hu, Tim Xiaoming ;

Elder, Kay ;

Snell, Philip ;

Christie, Leila ;

Robson, Paul ;

Niakan, Kathy K. .

DEVELOPMENT, 2015, 142 (20) :3613-3613

[3] DPPA2 and DPPA4 are dispensable for mouse zygotic genome activation and pre-implantation development [J].

Chen, Zhiyuan ;

Xie, Zhenfei ;

Zhang, Yi .

DEVELOPMENT, 2021, 148 (24)

[4] Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival [J].

Kubinyecz, Oana ;

Santos, Fatima ;

Drage, Deborah ;

Reik, Wolf ;

Eckersley-Maslin, Melanie A. .

DEVELOPMENT, 2021, 148 (24)

[5] Embryonic stem cell potency fluctuates with endogenous retrovirus activity [J].

Macfarlan, Todd S. ;

Gifford, Wesley D. ;

Driscoll, Shawn ;

Lettieri, Karen ;

Rowe, Helen M. ;

Bonanomi, Dario ;

Firth, Amy ;

Singer, Oded ;

Trono, Didier ;

Pfaff, Samuel L. .

NATURE, 2012, 487 (7405) :57-+

[6] Human pre-implantation embryo development [J].

Niakan, Kathy K. ;

Han, Jinnuo ;

Pedersen, Roger A. ;

Simon, Carlos ;

Pera, Renee A. Reijo .

DEVELOPMENT, 2012, 139 (05) :829-841

[7] Retrotransposons regulate host genes in mouse oocytes and preimplantation embryos [J].

Peaston, AE ;

Evsikov, AV ;

Graber, JH ;

de Vries, WN ;

Holbrook, AE ;

Solter, D ;

Knowles, BB .

DEVELOPMENTAL CELL, 2004, 7 (04) :597-606

[8] A LINE1-Nucleolin Partnership Regulates Early Development and ESC Identity [J].

Percharde, Michelle ;

Lin, Chih-Jen ;

Yin, Yafei ;

Guan, Juan ;

Peixoto, Gabriel A. ;

Bulut-Karslioglu, Aydan ;

Biechele, Steffen ;

Huang, Bo ;

Shen, Xiaohua ;

Ramalho-Santos, Miguel .

CELL, 2018, 174 (02) :391-+

[9] 8C-like cells capture the human zygotic genome activation program in vitro [J].

Taubenschmid-Stowers, Jasmin ;

Rostovskaya, Maria ;

Santos, Fatima ;

Ljung, Sebastian ;

Argelaguet, Ricard ;

Krueger, Felix ;

Nichols, Jennifer ;

Reik, Wolf .

CELL STEM CELL, 2022, 29 (03) :449-+

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