Multifunctional sonosensitizers in sonodynamic cancer therapy

被引：902

作者：

Son, Subin ^{[1
]}

Kim, Ji Hyeon ^{[1
]}

Wang, Xianwen ^{[2
]}

Zhang, Chuangli ^{[3
]}

Yoon, Shin A. ^{[4
]}

Shin, Jinwoo ^{[1
]}

Sharma, Amit ^{[5
]}

Lee, Min Hee ^{[4
]}

Cheng, Liang ^{[2
]}

Wu, Jiasheng ^{[3
]}

Kim, Jong Seung ^{[1
]}

机构：

[1] Korea Univ, Dept Chem, Seoul 02841, South Korea

[2] Soachow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Peoples R China

[3] Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China

[4] Sookmyung Womens Univ, Dept Chem, Seoul 04310, South Korea

[5] CSIR CSIO, Sect 30C, Chandigarh 160030, India

来源：

CHEMICAL SOCIETY REVIEWS | 2020年 / 49卷 / 11期

基金：

中国国家自然科学基金; 新加坡国家研究基金会;

关键词：

NANOPARTICLES; ULTRASOUND;

D O I：

10.1039/c9cs00648f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Phototherapy, including photodynamic therapy and photothermal therapy, has the potential to treat several types of cancer. However, to be an effective anticancer treatment, it has to overcome limitations, such as low penetration depth, low target specificity, and resistance conferred by the local tumor microenvironment. As a non-invasive technique, low-intensity ultrasound has been widely used in clinical diagnosis as it exhibits deeper penetration into the body compared to light. Recently, sonodynamic therapy (SDT), a combination of low-intensity ultrasound with a chemotherapeutic agent (sonosensitizer), has been explored as a promising alternative for cancer therapy. As all known cancer treatments such as chemotherapy, photodynamic therapy, photothermal therapy, immunotherapy, and drug delivery have been advanced independently enough to complement others substantially, the combination of these therapeutic modalities with SDT is opportune. This review article highlights the recent advances in SDT in terms of sonosensitizers and their formulations and anticancer therapeutic efficacy. Also discussed is the potential of SDT in combination with other modalities to address unmet needs in precision medicine.

引用

页码：3244 / 3261

页数：18

共 53 条

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