Pathogenic role of antiphospholipid antibodies

被引：72

作者：

Salmon, J. E. ^{[1
]}

de Groot, P. G. ^{[2
]}

机构：

[1] Cornell Univ, Hosp Special Surg, Weill Med Coll, Dept Med, New York, NY 10021 USA

[2] Univ Med Ctr, Dept Clin Chem & Haematol, Utrecht, Netherlands

来源：

LUPUS | 2008年 / 17卷 / 05期

关键词：

CIRCULATING ANGIOGENIC FACTORS; COMPLEMENT C3; TISSUE FACTOR; ACTIVATION; BETA(2)-GLYCOPROTEIN-I; C5A; RECEPTORS; IDENTIFICATION; TROPHOBLAST; HEMOSTASIS;

D O I：

10.1177/0961203308090025

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The antiphospholipid antibody syndrome (APS) is characterized by recurrent arterial and venous thrombosis and/or pregnancy in association with antiphospholipid (aPL) antibodies. The pathogenic mechanisms in APS that lead to in vivo injury are incompletely understood. Recent evidence suggests that APL antibodies alter regulation of haemostasis and induce activation of complement. We will discuss the current knowledge on how aPL antibodies trigger increased inflammation and enhanced thrombotic tendency, and thereby lead to tissue damage.

引用

页码：405 / 411

页数：7

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