A New Method for Enantiomeric Determination of 3,4-Methylenedioxymethamphetamine and p-Methoxymethamphetamine in Human Urine

被引：3
作者：
Chen, Wei-Jay [1 ]
Wu, Ren-Jang [2 ]
Yang, Hsueh-Hui [3 ]
Lua, Ahai-Chang [4 ]
Tzeng, Yin-Jeh [5 ]
Tuan, Shun-Hsing [6 ]
Chen, Liang [6 ]
Chou, Tsong-Yung [1 ]
机构：
[1] Tzu Chi Univ, Grad Inst Med Biotechnol, Dept Lab Med & Biotechnol, Hualien 970, Taiwan
[2] Providence Univ, Dept Appl Chem, Taichung 43301, Taiwan
[3] Buddhist Tzu Chi Med Fdn, Hualien Tzu Chi Hosp, Dept Med Res, Hualien 970, Taiwan
[4] Tzu Chi Univ, Ctr Drug Anal, Hualien 970, Taiwan
[5] Tzu Chi Univ, Dept Mol Biol & Human Genet, Hualien 970, Taiwan
[6] Tzu Chi Univ, Dept Med, Hualien 970, Taiwan
来源：
CHEMOSENSORS | 2022年 / 10卷 / 02期
关键词：
capillary immunoaffinity column; enantiomeric determination; LC-MS; MS; 3; 4-methylenedioxymethamphetamine; paramethoxymethamphetamine; AMPHETAMINE-TYPE STIMULANTS; QUANTIFICATION; MDMA; DERIVATIZATION; NEUROTOXICITY; SEPARATION; ECSTASY; DRUGS;
D O I：
10.3390/chemosensors10020050
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The abuse of paramethoxymethamphetamine (PMMA) and 3,4-methylenedioxymethamphetamine (MDMA) among young people is increasingly serious and has become a public health problem. Since enantiomers of MDMA and PMMA are metabolized at different rates in the body and exhibit different neurotoxicity in tissues, we have developed a simple method for simultaneous enantiomeric determination of PMMA and MDMA, using parallel dual capillary immunoaffinity columns coupled with tandem mass spectrometry. Linear calibration curves were obtained in concentration ranges of 100-1000 ng/mL, with a limit of quantitation of <22 ng/mL. Good interday accuracy and precision were achieved with this method. Besides filtering the urine sample through a 0.45 mu m MILLIPORE membrane, no other sample pretreatment was needed, and no toxic organic solvent was used. It is a rapid, environmentally friendly safe method, and could be applied for routine enantiomeric analysis of PMMA and MDMA in the pharmaceutical industry, forensic science, and environmental analysis.
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页数：10
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