Intramembrane Proteolysis in Regulated Protein Trafficking

被引：42

作者：

Lemberg, Marius K. ^{[1
]}

机构：

[1] Univ Heidelberg ZMBH, DKFZ ZMBH Allianz, Zentrum Mol Biol, D-69120 Heidelberg, Germany

来源：

TRAFFIC | 2011年 / 12卷 / 09期

关键词：

w gamma-secretase; ectodomain shedding; membrane protein; PARL; presenilin; proteostasis network; rhomboid; signaling; signal peptide peptidase; site-2protease; SIGNAL PEPTIDE PEPTIDASE; AMYLOID PRECURSOR PROTEIN; GAMMA-SECRETASE COMPLEX; VIRUS CORE PROTEIN; FAMILIAL ALZHEIMERS-DISEASE; RHOMBOID PROTEASE; MITOCHONDRIAL MORPHOLOGY; MEMBRANE-PROTEIN; DROSOPHILA RHOMBOID-1; INTRACELLULAR DOMAIN;

D O I：

10.1111/j.1600-0854.2011.01219.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Regulated intramembrane proteolysis is an evolutionarily conserved mechanism by which membrane-anchored bioactive molecules are released from cellular membranes. In eukaryotic cells, intramembrane proteases are found in different cellular organelles ranging from the endosomal system to mitochondria and chloroplasts. These proteases function in diverse processes such as transcription control, regulated growth factor secretion and recently even a role in the control of mitophagy has been suggested. Genomic annotation has predicted 13 different intramembrane proteases in humans. Apart from few studied examples, very little is known about their function. This review describes emerging principles of how intramembrane proteases contribute to the regulation of cellular protein trafficking in eukaryotic cells and raises the important question of how their activity is controlled.

引用

页码：1109 / 1118

页数：10

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