Clay nanotubes for encapsulation and sustained release of drugs

被引：237

作者：

Veerabadran, Nalinkanth G. ^{[1
]}

Price, Ronald R. ^{[2
]}

Lvov, Yuri M. ^{[1
]}

机构：

[1] Louisiana Tech Univ, Inst Micromfg, Ruston, LA 71272 USA

[2] Atlas Min Corp, Nanoclay & Technol Div, Eureka, UT 84628 USA

来源：

NANO | 2007年 / 2卷 / 02期

关键词：

halloysite; clay nanotubule; drug delivery; biocompatible;

D O I：

10.1142/S1793292007000441

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

50-nm diameter halloysite clay nanotubules with 15 nm lumen were used for loading poorly soluble drugs and sustaining their release. Loading was optimized by varying pH and alcohol/ water ratio in the solvent with a maximum drug loading of 12 volume%. Near linear release of Dexamethasone, Furosemide, and Nifedipine was demonstrated for 5-10 hours. Its capacity for the time release of drugs, along with its simple loading procedure and the biocompatibility of halloysite nanotubules makes this method a prospective drug delivery system.

引用

页码：115 / 120

页数：6

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