Clay nanotubes for encapsulation and sustained release of drugs

被引：236
作者：
Veerabadran, Nalinkanth G. [1 ]
Price, Ronald R. [2 ]
Lvov, Yuri M. [1 ]
机构：
[1] Louisiana Tech Univ, Inst Micromfg, Ruston, LA 71272 USA
[2] Atlas Min Corp, Nanoclay & Technol Div, Eureka, UT 84628 USA
来源：
NANO | 2007年 / 2卷 / 02期
关键词：
halloysite; clay nanotubule; drug delivery; biocompatible;
D O I：
10.1142/S1793292007000441
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
50-nm diameter halloysite clay nanotubules with 15 nm lumen were used for loading poorly soluble drugs and sustaining their release. Loading was optimized by varying pH and alcohol/ water ratio in the solvent with a maximum drug loading of 12 volume%. Near linear release of Dexamethasone, Furosemide, and Nifedipine was demonstrated for 5-10 hours. Its capacity for the time release of drugs, along with its simple loading procedure and the biocompatibility of halloysite nanotubules makes this method a prospective drug delivery system.
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收藏
页码：115 / 120
页数：6
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