Notch signaling from tumor cells: A new mechanism of angiogenesis

被引：115

作者：

Li, JL ^{[1
]}

Harris, AL ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Canc Res UK Mol Oncol Labs, Weatherall Inst Mol Med, Oxford OX3 9DS, England

来源：

CANCER CELL | 2005年 / 8卷 / 01期

关键词：

D O I：

10.1016/j.ccr.2005.06.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Notch signaling is an evolutionarily conserved pathway and plays key roles in embryonic vascular development and angiogenesis. Multiple components of the Notch pathway are expressed in vasculature, and mice deficient for a variety of these components display embryonic lethality with vascular remodeling defects. Alteration of Notch signaling in various endothelial cells generates profound effects on angiogenesis in vitro. New evidence shows that Notch signaling from tumor cells is able to activate endothelial cells and trigger tumor angiogenesis in vitro and in a xenograft mouse tumor model. Selective interruption of Notch signaling within tumors may provide an antiangiogenic strategy.

引用

页码：1 / 3

页数：3