Characteristic properties of genipin as an activator in neuronal nitric oxide synthase

被引：13
作者：
Suzuki, Hirokazu [2 ,3 ]
Yamazaki, Matsumi [1 ]
Chiba, Kenzo [1 ,3 ]
Sawanishi, Hiroyuki [2 ,3 ]
机构：
[1] Hokuriku Univ, Fac Pharmaceut Sci, Dept Biochem, Kanazawa, Ishikawa 9201181, Japan
[2] Hokuriku Univ, Dept Med Chem, Kanazawa, Ishikawa 9201181, Japan
[3] Hokuriku Univ, Org Frontier Prevent Pharmaceut Sci, Kanazawa, Ishikawa 9201181, Japan
来源：
JOURNAL OF HEALTH SCIENCE | 2007年 / 53卷 / 06期
关键词：
genipin; tetrahydrobiopterin; 4-aminotetrahydrobiopterin; molecular modeling; neuronal nitric oxide synthase;
D O I：
10.1248/jhs.53.730
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
The present investigation was undertaken to compare the structural and electronic properties of genipin with those of tetrahydrobiopterin (H(4)B), an essential cofactor in neuronal nitric oxide synthase (nNOS), and 4-aminotetrahydrobiopterin (4-amino-H(4)B), an inhibitor of nNOS, using computer-assisted molecular modeling techniques. Molecular modeling, superimposing, and docking simulation, in addition to LUMO-energy calculation, revealed that genipin has structural and electronic properties that markedly resemble those of H(4)B.
引用
收藏
页码：730 / 733
页数：4
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