Translational control by CPEB: A means to the end

被引：473
作者：
Mendez, R [1 ]
Richter, JD [1 ]
机构：
[1] Univ Massachusetts, Sch Med, Dept Mol Genet & Microbiol, Worcester, MA 01655 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 07期
关键词：
D O I：
10.1038/35080081
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The regulated translation of messenger RNA is essential for cell-cycle progression, establishment of the body plan during early development, and modulation of key activities in the central nervous system. Cytoplasmic polyadenylation, which is one mechanism of controlling translation, is driven by CPEB - a highly conserved, sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element, and modulates translational repression and mRNA localization. What are the features and functions of this multifaceted protein?
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页码：521 / 529
页数：9
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