Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice

被引：17

作者：

Elia, Evelin M. ^{[1
]}

Pustovrh, Carolina ^{[2
,3
]}

Amalfi, Sabrina ^{[1
]}

Devoto, Luigi ^{[3
]}

Beatriz Motta, Alicia ^{[1
]}

机构：

[1] Consejo Nacl Invest Cient & Tecnol CONICET, Ctr Estudios Farmacol & Bot CEFYBO, RA-2155 Buenos Aires, DF, Argentina

[2] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Inst Fisiol Biol Mol & Neurociencia IFIBYNE, Buenos Aires, DF, Argentina

[3] Univ Chile, Hosp Clin San Borja Arriaran, Inst Invest Materno Infantil, Fac Med, Santiago, Chile

来源：

FERTILITY AND STERILITY | 2011年 / 95卷 / 08期

关键词：

Lipoxygenases; metformin; peroxisome proliferator activated receptor gamma; polycystic ovary syndrome; uterus; POLYCYSTIC-OVARY-SYNDROME; PPAR-GAMMA; PROGESTERONE-RECEPTOR; INSULIN-RESISTANCE; PROTEIN-KINASE; WOMEN; DEHYDROEPIANDROSTERONE; PREGNANCY; CYCLOOXYGENASE-2; LIPOXYGENASES;

D O I：

10.1016/j.fertnstert.2011.02.004

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Chronic hyperandrogenism alters the peroxisome proliferator-activated receptor gamma (PPAR gamma) pathway in the uterine tissue of prepubertal mice. The gene and protein expression of PPAR gamma is not modified, but the gene and protein expression of 12-lipoxygenase (12-LOX), an enzyme that synthesizes PPAR gamma ligands, is decreased. The antihyperglycemic drug metformin can prevent this adverse effect. (Fertil Steril (R) 2011;95:2534-7. (C) 2011 by American Society for Reproductive Medicine.)

引用

页码：2534 / U556

页数：5

共 38 条

[1] MISCARRIAGE RATES FOLLOWING INVITRO FERTILIZATION ARE INCREASED IN WOMEN WITH POLYCYSTIC OVARIES AND REDUCED BY PITUITARY DESENSITIZATION WITH BUSERELIN [J].