Role of umbilical cord arterial pH and lactate in newborn assessment of term antenatal women with hypertensive disorders of pregnancy

被引:3
作者
Kumar, Naina [1 ]
Yadav, Ashu [2 ]
机构
[1] All India Inst Med Sci, Dept Obstet & Gynecol, Guntur 522503, Andhra Pradesh, India
[2] Maharishi Markandeshwar Inst Med Sci & Res, Dept Obstet & Gynecol, Ambala, Haryana, India
来源
CLINICAL EPIDEMIOLOGY AND GLOBAL HEALTH | 2020年 / 8卷 / 03期
关键词
Hypertension; Hypoxic ischemic encephalopathy; Neonate; Pregnancy; Umbilical cord; DEHYDROGENASE-ACTIVITY; BLOOD; DIAGNOSIS; INFANTS; VALUES; ASPHYXIA;
D O I
10.1016/j.cegh.2020.02.026
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Problem: To know role of cord arterial blood pH and lactate dehydrogenase levels in neonatal outcome assessment. Methods: Present observational study was conducted in Obstetrics and Gynecology department of a rural tertiary center of Northern India over 6 months (July-January 2019) on 155 term (>= 37-<= 42 weeks) antenatal women with hypertensive disorders of pregnancy fulfilling inclusion criteria. Immediately after delivery, arterial blood sample was drawn from doubly clamped 10-12 cm long umbilical cord in pre-heparinized insulin syringe, which was sent for pH estimation and 0.5 ml in lithium heparin tube for lactate dehydrogenase levels. One- and 5-min neonatal Apgar score was noted by pediatrician. Cord blood pH and lactate levels were then compared with overall neonatal outcome. Statistical analysis was done using SPSS-22 version. Results: Mean values of umbilical cord arterial pH and LDH was 7.2 +/- 0.1 and 449.5 +/- 562.9 U/L respectively. Significantly low mean cord blood pH (7.03 +/- 0.12) and high LDH levels (939.74 +/- 781.75 U/L) were observed in neonates of eclamptic mothers (p = 0.00). Mode of delivery had significant effects on cord blood parameters with significantly low pH and elevated LDH levels seen in neonates delivered by emergency LSCS for fetal distress (p < 0.05). Cord blood LDH levels were more significantly associated with NICU admission, neonatal morbidity and mortality. Cord blood LDH was a better predictor of neonatal outcome with 100% sensitivity and 79.73% specificity. Conclusion: Cord arterial blood lactate dehydrogenase levels were better predictor of overall neonatal outcome.
引用
收藏
页码:927 / 933
页数:7
相关论文
共 39 条
  • [1] Umbilical lactate as a measure of acidosis and predictor of neonatal risk: a systematic review
    Allanson, E. R.
    Waqar, T.
    White, C. R. H.
    Tancalp, O.
    Dickinson, J. E.
    [J]. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2017, 124 (04) : 584 - 594
  • [2] [Anonymous], 2015, Obstet Gynecol, V125, P521, DOI 10.1097/01.AOG.0000460762.59152.d7
  • [3] [Anonymous], 2011, NICE clinical guideline 132 - Caesarean section
  • [4] [Anonymous], 2016, Int J Reprod Contracept Obstet Gynecol
  • [5] [Anonymous], 2005, The World Health Report
  • [6] [Anonymous], J NEONATAL BIOL
  • [7] [Anonymous], WEBMED CENT OBSTET G
  • [8] [Anonymous], 2016, INT J SCI STUD
  • [9] Armstrong L, 2007, ARCH DIS CHILD-FETAL, V92, P430
  • [10] Effect of delayed sampling on umbilical cord arterial and venous lactate and blood gases in clamped and unclamped vessels
    Armstrong, L.
    Stenson, B.
    [J]. ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 2006, 91 (05): : 342 - 345