Thyroid hormonal axis regulates protein C anticoagulation pathway in rats

被引：0
作者：
Negrev, Negrin [1 ]
Nyagolov, Yuri [2 ]
Stefanova, Margarita [1 ]
Stancheva, Emiliya [1 ]
机构：
[1] Med Univ, Dept Physiol, Varna 9300, Bulgaria
[2] Med Univ Sofia, Dept Physiol, Sofia 1432, Bulgaria
来源：
CENTRAL EUROPEAN JOURNAL OF BIOLOGY | 2011年 / 6卷 / 04期
关键词：
Hypothalamic-pituitary-thyroid axis; Protein C antigen; Protein C activity; Protein S; Anticoagulation; BLOOD-COAGULATION; RISK-FACTOR; HEMOSTASIS; MECHANISMS; THYROXINE; THROMBIN; RECEPTOR; SYSTEM;
D O I：
10.2478/s11535-011-0031-y
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Effects of the hormones of the hypothalamic-pituitary-thyroid axis on some basic parameters of the activity of protein C anticoagulation pathway in rats are studied. Thyrotropin-releasing hormone (0.06 mg/kg body mass), thyrotropin (1 IU/kg), triiodothyronine (T3) (0.08 mg/kg), thyroxine (T4) (0.08 mg/kg), administered subcutaneously for three consecutive days on four different groups of rats increased significantly activated protein C, free protein S and protein S activity, and reduced the soluble endothelial protein C receptor. Protein C antigen and total protein S were significantly elevated only by thyrotropin-releasing hormone and thyroid-stimulating hormone, but they were not affected by T3 and T4 treatment. The data indicate the hypothalamic-pituitary-thyroid axis is involved in the regulation of the protein C anticoagulation pathway in rats by activation of this system, suggesting a tendency of hypocoagulability.
引用
收藏
页码：518 / 523
页数：6
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