Emerging roles of epigenetic mechanisms in the enduring effects of early-life stress and experience on learning and memory

被引：81

作者：

McClelland, Shawn ^{[2
]}

Korosi, Aniko ^{[2
]}

Cope, Jessica ^{[2
]}

Ivy, Autumn ^{[2
]}

Baram, Tallie Z. ^{[1
,2
]}

机构：

[1] Univ Calif Irvine, ZOT 4475, Dept Anat Neurobiol, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Dept Pediat & Neurol, Irvine, CA 92697 USA

来源：

NEUROBIOLOGY OF LEARNING AND MEMORY | 2011年 / 96卷 / 01期

关键词：

Hippocampus; Neonatal; Maternal care; Corticotropin releasing hormone; Glucocorticoids; Neuroplasticity; Programming; Resilience; CORTICOTROPIN-RELEASING HORMONE; RESTRICTIVE SILENCER FACTOR; LONG-TERM POTENTIATION; MEDIAL TEMPORAL-LOBE; IMMATURE RAT MODEL; SYNAPTIC PLASTICITY; PARAVENTRICULAR NUCLEUS; GENE-TRANSCRIPTION; MATERNAL-CARE; CORTICOSTEROID RECEPTORS;

D O I：

10.1016/j.nlm.2011.02.008

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Epigenetic mechanisms are involved in programming gene expression throughout development. In addition, they are key contributors to the processes by which early-life experience fine-tunes the expression levels of key neuronal genes, governing learning and memory throughout life. Here we describe the long-lasting, bi-directional effects of early-life experience on learning and memory. We discuss how enriched postnatal experience enduringly augments spatial learning, and how chronic early-life stress results in persistent and progressive deficits in the structure and function of hippocampal neurons. The existing and emerging roles of epigenetic mechanisms in these fundamental neuroplasticity phenomena are illustrated. (c) 2011 Elsevier Inc. All rights reserved.

引用

页码：79 / 88

页数：10

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