Discovery of a novel and potent, and urea isostere inhibitors series of dianilinopyrimidineurea of VEGFR2 tyrosine kinase

被引：33

作者：

Sammond, DM ^{[1
]}

Nallor, KE ^{[1
]}

Veal, JM ^{[1
]}

Nolte, RT ^{[1
]}

Wang, LP ^{[1
]}

Knick, VB ^{[1
]}

Rudolph, SK ^{[1
]}

Truesdale, AT ^{[1
]}

Nartey, EN ^{[1
]}

Stafford, JA ^{[1
]}

Kumar, R ^{[1
]}

Cheung, M ^{[1
]}

机构：

[1] GlaxoSmithKline, Res Triangle Pk, NC 27709 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 15期

关键词：

VEGFR2; FLK-1; KDR; kinase inhibitor;

D O I：

10.1016/j.bmcl.2005.05.096

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：3519 / 3523

页数：5

共 50 条

[31] Anlotinib, a novel small molecular tyrosine kinase inhibitor, suppresses growth and metastasis via dual blockade of VEGFR2 and MET in osteosarcoma
Wang, Gangyang
Sun, Mengxiong
Jiang, Yafei
Zhang, Tao
Sun, Wei
Wang, Hongsheng
Yin, Fei
Wang, Zhuoying
Sang, Weilin
Xu, Jing
Mao, Min
Zuo, Dongqing
Zhou, Zifei
Wang, Chongren
Fu, Zeze
Wang, Zongyi
Duan, Zhenfeng
Hua, Yingqi
Cai, Zhengdong
INTERNATIONAL JOURNAL OF CANCER, 2019, 145 (04) : 979 - 993
[32] Discovery of benzimidazole derivatives as novel multi-target EGFR, VEGFR-2 and PDGFR kinase inhibitors
Li, Yunqi
Tan, Chunyan
Gao, Chunmei
Zhang, Cunlong
Luan, Xudong
Chen, Xiaowu
Liu, Hongxia
Chen, Yuzong
Jiang, Yuyang
BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19 (15) : 4529 - 4535
[33] Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties
Wang, Xiaojing
Barbosa, James
Blomgren, Peter
Bremer, Meire C.
Chen, Jacob
Crawford, James J.
Deng, Wei
Dong, Liming
Eigenbrot, Charles
Gallion, Steve
Hau, Jonathon
Hu, Huiyong
Johnson, Adam R.
Katewa, Arna
Kropf, Jeffrey E.
Lee, Seung H.
Liu, Lichuan
Lubach, Joseph W.
Macaluso, Jen
Maciejewski, Pat
Mitchell, Scott A.
Ortwine, Daniel F.
DiPaolo, Julie
Reif, Karin
Scheerens, Heleen
Schmitt, Aaron
Wong, Harvey
Xiong, Jin-Ming
Xu, Jianjun
Zhao, Zhongdong
Zhou, Fusheng
Currie, Kevin S.
Young, Wendy B.
ACS MEDICINAL CHEMISTRY LETTERS, 2017, 8 (06): : 608 - 613
[34] Discovery of dual kinase inhibitors targeting VEGFR2 and FAK: structure-based pharmacophore modeling, virtual screening, and molecular docking studies
Fouad, Marwa A.
Osman, Alaa A.
Abdelhamid, Noha M.
Rashad, Mai W.
Nabawy, Ashrakat Y.
El Kerdawy, Ahmed M.
BMC CHEMISTRY, 2024, 18 (01)
[35] Discovery of dual kinase inhibitors targeting VEGFR2 and FAK: structure-based pharmacophore modeling, virtual screening, and molecular docking studies
Marwa A. Fouad
Alaa A. Osman
Noha M. Abdelhamid
Mai W. Rashad
Ashrakat Y. Nabawy
Ahmed M. El Kerdawy
BMC Chemistry, 18
[36] New application of novel tetrazine derivatives as potent VEGFR-2 kinase inhibitors and anti-cancer agents
Zheng, Quan
Cheng, Kang
Jin, Hao
Zhang, Wen
Rao, Guo-Wu
FUTURE MEDICINAL CHEMISTRY, 2022, 14 (17) : 1251 - 1266
[37] Novel VEGFR-2 kinase inhibitors identified by the back-to-front approach
Sanphanya, Kingkan
Wattanapitayakul, Suvara K.
Phowichit, Suwadee
Fokin, Valery V.
Vajragupta, Opa
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (10) : 2962 - 2967
[38] Characterisation of tyrosine kinase inhibitor-receptor interactions at VEGFR2 using sunitinib-red and nanoBRET
Van Daele, Marieke
Kilpatrick, Laura E.
Woolard, Jeanette
Hill, Stephen J.
BIOCHEMICAL PHARMACOLOGY, 2023, 214
[39] Anticancer potential of novel benzothiazolyl piperidine-3-carboxamide derivatives as CDKs and VEGFR2 multi-target kinase inhibitors
Afzal, Obaid
Altharawi, Ali
Alqahtani, Safar M.
Alossaimi, Manal A.
Aldakhil, Taibah
Altamimi, Abdulmalik S. A.
Alabbas, Alhumaidi
Alamri, Mubarak A.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2025, 39 (01)
[40] Protein-ligand interaction-guided discovery of novel VEGFR-2 inhibitors
Zhang, Yanmin
Zhang, Mingliang
Wang, Yuchen
Fan, Yuanrong
Chen, Xingye
Yang, Yan
Hua, Yi
Xie, Wuchen
Lu, Tao
Tang, Weifang
Chen, Yadong
Liu, Haichun
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2020, 38 (09) : 2559 - 2574

← 1 2 3 4 5 →