Near-Infrared Thermally Activated Delayed Fluorescence Nanoparticle: A Metal-Free Photosensitizer for Two-Photon-Activated Photodynamic Therapy at the Cell and Small Animal Levels

被引:95
作者
Fang, Fang [1 ]
Yuan, Yi [2 ,3 ]
Wan, Yingpeng [3 ,4 ]
Li, Jing [5 ]
Song, Yueyue [1 ]
Chen, Wen-Cheng [6 ]
Zhao, Dongxu [1 ]
Chi, Yun [2 ,3 ]
Li, Menglin [7 ]
Lee, Chun-Sing [3 ,4 ]
Zhang, Jinfeng [1 ]
机构
[1] Beijing Inst Technol, Sch Life Sci, Key Lab Mol Med & Biotherapy, Beijing 100081, Peoples R China
[2] City Univ Hong Kong, Dept Mat Sci & Engn, Kowloon, 83 Tat Chee Ave, Hong Kong 999077, Peoples R China
[3] City Univ Hong Kong, Dept Chem, Kowloon, 83 Tat Chee Ave, Hong Kong 999077, Peoples R China
[4] City Univ Hong Kong, Ctr Super Diamond & Adv Films COSDAF, Kowloon, 83 Tat Chee Ave, Hong Kong 999077, Peoples R China
[5] Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China
[6] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Peoples R China
[7] Beijing Inst Technol, Sch Mat Sci & Engn, Beijing 100081, Peoples R China
基金
中国国家自然科学基金; 北京市自然科学基金;
关键词
metal-free photosensitizers; near-infrared emission; photodynamic therapy; thermally activated delayed fluorescence (TADF); two-photon activated photodynamic therapy; MOLECULAR DESIGN; IN-VITRO; EFFICIENCY; EMITTERS; BODIPY;
D O I
10.1002/smll.202106215
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Thermally activated delayed fluorescence (TADF) materials with extremely small singlet-triplet energy offsets have opened new horizons for the development of metal-free photosensitizers for photodynamic therapy (PDT) in recent years. However, the exploration of near-infrared (NIR) TADF emitters for efficient two-photon-excited (TPE) PDT is still a formidable challenge, thus it has not been reported yet. In this study, purely organic photosensitizers (PSs) based on the TADF nanoparticles (NIR-TADF NPs) are designed for efficient TPE-PDT, which show excellent singlet oxygen generation ability. Thanks to the intrinsic two-photon excitation and NIR emission characteristics, the NIR-TADF NPs demonstrate promising potential in both single-photon-excited (SPE) and TPE NIR imaging. More importantly, the anti-tumor efficiency and biosafety of TADF-based PSs at the small animal level are confirmed in A549 tumor xenograft models under TPE laser irradiance, which will facilitate the practical biomedical applications of TADF materials. This work not only provides a promising strategy to develop metal-free PSs, but also expands the applied scope of TADF-based nanotherapeutics and advances their possible clinical translation in cancer therapy.
引用
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页数:10
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