Role of Nitric Oxide and Flavohemoglobin Homolog Genes in Aspergillus nidulans Sexual Development and Mycotoxin Production

被引：56
作者：
Baidya, Sachin [1 ]
Cary, Jeffrey W. [2 ]
Grayburn, W. Scott [1 ]
Calvo, A. M. [1 ]
机构：
[1] No Illinois Univ, Dept Biol Sci, De Kalb, IL 60115 USA
[2] Agr Res Serv, So Reg Res Ctr, USDA, New Orleans, LA USA
来源：
APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2011年 / 77卷 / 15期
关键词：
TRANSCRIPTION FACTOR; EXPRESSION; SYNTHASE; DIOXYGENASE; HEMOGLOBINS;
D O I：
10.1128/AEM.00638-11
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Flavohemoglobins are widely distributed in both prokaryotes and eukaryotes. These proteins are involved in reducing nitric oxide levels. Deletion of the Aspergillus nidulans flavohemoglobin gene fhbA induced sexual development and decreased sterigmatocystin production. Supplementation with a nitric oxide-releasing compound promoted cleistothecial formation and increased nsdD and steA expression, indicating that nitric oxide induces sexual development. This is the first study on the effect of nitric oxide on morphogenesis and secondary metabolism in fungi.
引用
收藏
页码：5524 / 5528
页数：5
相关论文
共 31 条
  • [1] Mycotoxins
    Bennett, JW
    Klich, M
    [J]. CLINICAL MICROBIOLOGY REVIEWS, 2003, 16 (03) : 497 - +
  • [2] Phylogeny of fungal hemoglobins and expression analysis of the Aspergillus oryzae flavohemoglobin gene fhbA during hyphal growth
    Biesebeke, Rob Te
    Levasseur, Anthony
    Boussier, Amandine
    Record, Eric
    Van den Hondel, Cees A. M. J. J.
    Punt, Peter J.
    [J]. FUNGAL BIOLOGY, 2010, 114 (2-3) : 135 - 143
  • [3] REGULATION OF ASPERGILLUS MYCOTOXIN BIOSYNTHESIS
    Cary, Jeffrey W.
    Calvo, Ana M.
    [J]. TOXIN REVIEWS, 2008, 27 (3-4) : 347 - 370
  • [4] Yeast flavohemoglobin, a nitric oxide oxidoreductase, is located in both the cytosol and the mitochondrial matrix
    Cassanova, N
    O'Brien, KM
    Stahl, BT
    McClure, T
    Poyton, RO
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (09) : 7645 - 7653
  • [5] Nitric oxide and iron proteins
    Cooper, CE
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1999, 1411 (2-3): : 290 - 309
  • [6] Role for the Salmonella flavohemoglobin in protection from nitric oxide
    Crawford, MJ
    Goldberg, DE
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (20) : 12543 - 12547
  • [7] Neuronal nitric oxide synthase and calbindin delineate sex differences in the developing hypothalamus and preoptic area
    Edelmann, Michelle
    Wolfe, Cory
    Scordalakes, Elka M.
    Rissman, Emilie F.
    Tobet, Stuart
    [J]. DEVELOPMENTAL NEUROBIOLOGY, 2007, 67 (10) : 1371 - 1381
  • [8] Nitric-oxide dioxygenase activity and function of flavohemoglobins - Sensitivity to nitric oxide and carbon monoxide inhibition
    Gardner, PR
    Gardner, AM
    Martin, LA
    Dou, Y
    Li, TS
    Olson, JS
    Zhu, H
    Riggs, AF
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (41) : 31581 - 31587
  • [9] Nitric oxide dioxygenase: An enzymic function for flavohemoglobin
    Gardner, PR
    Gardner, AM
    Martin, LA
    Salzman, AL
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (18) : 10378 - 10383
  • [10] The nsdD gene encodes a putative GATA-type transcription factor necessary for sexual development of Aspergillus nidulans
    Han, KH
    Han, KY
    Yu, JH
    Chae, KS
    Jahng, KY
    Han, DM
    [J]. MOLECULAR MICROBIOLOGY, 2001, 41 (02) : 299 - 309
1234