Role of Nitric Oxide and Flavohemoglobin Homolog Genes in Aspergillus nidulans Sexual Development and Mycotoxin Production

被引：56

作者：

Baidya, Sachin ^{[1
]}

Cary, Jeffrey W. ^{[2
]}

Grayburn, W. Scott ^{[1
]}

Calvo, A. M. ^{[1
]}

机构：

[1] No Illinois Univ, Dept Biol Sci, De Kalb, IL 60115 USA

[2] Agr Res Serv, So Reg Res Ctr, USDA, New Orleans, LA USA

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2011年 / 77卷 / 15期

关键词：

TRANSCRIPTION FACTOR; EXPRESSION; SYNTHASE; DIOXYGENASE; HEMOGLOBINS;

D O I：

10.1128/AEM.00638-11

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Flavohemoglobins are widely distributed in both prokaryotes and eukaryotes. These proteins are involved in reducing nitric oxide levels. Deletion of the Aspergillus nidulans flavohemoglobin gene fhbA induced sexual development and decreased sterigmatocystin production. Supplementation with a nitric oxide-releasing compound promoted cleistothecial formation and increased nsdD and steA expression, indicating that nitric oxide induces sexual development. This is the first study on the effect of nitric oxide on morphogenesis and secondary metabolism in fungi.

引用

页码：5524 / 5528

页数：5

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