Microwave assisted one pot synthesis of 2-alkyl amino benzimidazoles, 2-alkyl amino benzoxazoles and 2-alkyl amino benzthiazoles by using various carbodiimides

被引：4

作者：

Rapolu, Thirupathi ^{[1
,3
]}

Naveen, Polkam ^{[2
]}

Kumar, K. V. P. Pavan ^{[1
]}

Leleti, Krishnakanth Reddy ^{[1
,4
]}

Korapolu, Raghubabu ^{[3
]}

机构：

[1] GVK Biosci Pvt Ltd, IDA Nacharam, Chem Serv, Hyderabad 500076, India

[2] Jawaharlal Nehru Technol Univ Hyderabad, Ctr Chem Sci & Technol, IST, Hyderabad 500085, Telangana, India

[3] Andhra Univ, Coll Engn A, Dept Engn C, Visakhapatnam 530003, Andhra Pradesh, India

[4] Sai Lifesci Ltd, Med Chem Div, DS-7,ICICI Knowledge Pk, Hyderabad 500078, India

来源：

RESULTS IN CHEMISTRY | 2022年 / 4卷

关键词：

2-aminobenzimidazole; 2-aminobenzoxazole; 2-aminobenzthiazole; Bioisosteres; Carbodiimide; Microwave irradiation technique; PHASE COMBINATORIAL SYNTHESIS; EFFICIENT SYNTHESIS; CATALYZED SYNTHESIS; O-HALOANILINES; SNAR REACTION; DERIVATIVES; 2-AMINOBENZIMIDAZOLES; AMINATION; INDOLES; 2-AMINOBENZOXAZOLES;

D O I：

10.1016/j.rechem.2022.100351

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A library of bioisosteres namely 2-amino substituted benzimidazole, 2-amino substituted benzoxazole, 2-amino substituted benzthiazole derivatives has been synthesized by an efficient ligand free, zinc catalysed one-pot cascade microwave irradiation technique has been developed. The procedure starts with coupling of various carbodiimides with appropriately substituted o-phenylendiamine, o-aminophenol, o-aminothiols to give the corresponding derivatives in excellent yields.

引用

页数：8

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