Rhodium-Catalyzed Selective C-H Activation/Olefination of Phenol Carbamates

被引：174

作者：

Gong, Tian-Jun ^{[1
]}

Xiao, Bin ^{[1
,2
]}

Liu, Zhao-Jing ^{[1
]}

Wan, Jian ^{[1
]}

Xu, Jun ^{[1
]}

Luo, Dong-Fen ^{[1
]}

Fu, Yao ^{[1
]}

Liu, Lei ^{[1
,2
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Joint Lab Green Synthet Chem, Hefei 230026, Peoples R China

[2] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 12期

关键词：

INTERNAL ALKYNES; BOND ACTIVATION; OLEFINATION; FUNCTIONALIZATION; ARENES; ACIDS; COUPLING/CYCLIZATION; ALKENYLATION; TEMPERATURE; DERIVATIVES;

D O I：

10.1021/ol201140q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rh(III)-catalyzed ortho C-H activation/olefination of phenol carbamates has been developed. High regioselectivity is observed with a range of phenol carbamates enabling efficient coupling with acrylates and styrenes. This reaction exhibits different reactivity as compared to the Pd-catalyzed ortho-arylation reaction of phenol esters and provides a new approach for the synthesis of ortho-substituted phenols.

引用

页码：3235 / 3237

页数：3

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