HPLC and HPTLC assays for the antimalarial agents Chloroquine, Primaquine and Bulaquine

被引：25

作者：

Dwivedi, AK ^{[1
]}

Saxena, D ^{[1
]}

Singh, S ^{[1
]}

机构：

[1] Cent Drug Res Inst, Div Pharmaceut, Lucknow 226001, Uttar Pradesh, India

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2003年 / 33卷 / 04期

关键词：

antirelapse; antimalarial; Bulaquine; Primaquine; Chloroquine; simultaneous estimation; HPLQ; HPTLC;

D O I：

10.1016/S0731-7085(03)00355-8

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A combination Kit for antirelapse treatment of P. vivax malaria, consisting of Chloroquine phosphate tablets and Bulaquine capsules has been recently developed, and marketed under the trade name Aablaquine. Bulaquine is prepared from Primaquine. Several methods of analysis are reported for each drug separately as well two drugs in combination but no method for simultaneous estimation of these three drugs is known. Therefore, the present study was undertaken to develop a sensitive and reproducible high performance liquid chromatographic as well as high performance thin layer chromatographic assay method for the simultaneous estimation of Chloroquine, Primaquine and Bulaquine. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：851 / 858

页数：8

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