The NEDD4-USP13 axis facilitates autophagy via deubiquitinating PIK3C3

被引：18

作者：

Xie, Weihong ^{[1
]}

Jin, Shouheng ^{[1
]}

Cui, Jun ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, MOE Key Lab Gene Funct & Regulat, Guangzhou 510275, Guangdong, Peoples R China

来源：

AUTOPHAGY | 2020年 / 16卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Auto-ubiquitination; autophagy; deubiquitination complex; NEDD4; USP13;

D O I：

10.1080/15548627.2020.1743071

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Macroautophagy/autophagy, an evolutionarily conserved eukaryotic bioprocess, plays an important role in the bulk degradation of intracellular macromolecules, organelles, and invading pathogens. PIK3C3/VPS34 (phosphatidylinositol 3-kinase catalytic subunit type 3) functions as a key protein in autophagy initiation and progression. The activity of PIK3C3 is tightly regulated by multiple post-translational modifications, including ubiquitination, however, the regulatory mechanisms underpinning the reversible deubiquitination of PIK3C3 remain poorly understood. Recently, we identified the E3 ubiquitin ligase NEDD4/NEDD4-1 as a positive regulator of autophagy through decreasing the K48-linked ubiquitination of PIK3C3 by recruiting USP13.

引用

页码：1150 / 1151

页数：2