Synthesis, structural characterization and biological activity against several human tumor cell lines of four rhenium(I) diseleno-ethers complexes: Re(CO)3Cl(PhSe(CH2)2SePh), Re(CO)3Cl(PhSe(CH2)3SePh), Re(CO)3Cl(HO2C-CH2Se(CH2)2SeCH2-CO2H) and Re(CO)3Cl(HO2C-CH2Se(CH2)3SeCH2-CO2H)

被引：27
|
作者：
Kermagoret, Anthony [1 ]
Morgant, Georges [1 ]
d'Angelo, Jean [1 ]
Tomas, Alain [2 ]
Roussel, Pascal [3 ]
Bastian, Gerard [4 ]
Collery, Philippe [5 ]
Desmaele, Didier [1 ]
机构：
[1] Univ Paris Sud, UMR CNRS 8076, Lab BioCIS, IFR 141,Fac Pharm, F-92296 Chatenay Malabry, France
[2] Univ Paris 05, UMR CNRS 8015, Lab Cristallog & RMN Biol, Fac Pharm, F-75005 Paris, France
[3] Ecole Natl Super Chim Lille, UMR CNRS 8181, Unite Catalyse & Chim Solide, F-59652 Villeneuve Dascq, France
[4] CHU Pitie Salpetriere, Pharmacol Lab, F-75013 Paris, France
[5] Soc Coordinat Rech Therapeut, F-20200 Algajola, France
来源：
POLYHEDRON | 2011年 / 30卷 / 02期
关键词：
Rhenium(I) complexes; Diseleno-ethers ligands; X-ray structures; Cytotoxicity; MTT; NUCLEAR MAGNETIC-RESONANCE; CRYSTAL-STRUCTURE; TRICARBONYL COMPLEXES; CYTOTOXICITY; COMPOUND; BEHAVIOR; LIGANDS;
D O I：
10.1016/j.poly.2010.10.026
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Four novel rhenium(I) diseleno-ethers complexes, namely Re(CO)(3)Cl(PhSe(CH2)(2)SePh) (5), Re(CO)(3)Cl(PhSe(CH2)(3)SePh-(6),Re(CO)(3)Cl(HO2C-CH2Se(CH2)(2)SeCH2-CO2H)(7) and Re(CO)(3)Cl(HO2C-CH2Se(CH2)(3)SeCH2-CO2H) (8), have been synthesized by reaction of Re(CO)(5)Cl with the corresponding bidentate ligands. Structures of 5 and 6 were established by single-crystal X-ray diffraction analysis. Complexes 7 and 8 were identified by elemental analysis, H-1 NMR-, IR- and mass spectroscopy. The antiproliferative activity of these complexes against four solid human tumor cells was determined. The water-soluble disodium salts of complexes 7 and 8 exhibited marked activities against MCF-7 breast cancer cells. (C) 2010 Elsevier Ltd. All rights reserved.
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收藏
页码：347 / 353
页数：7
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