Requirement of the agr Locus for Colony Spreading of Staphylococcus aureus

被引：57
|
作者：
Tsompanidou, Eleni [1 ,2 ]
Sibbald, Mark J. J. B. [1 ,2 ]
Chlebowicz, Monika A. [1 ,2 ]
Dreisbach, Annette [1 ,2 ]
Back, Jaap Willem [3 ]
van Dijl, Jan Maarten [1 ,2 ]
Buist, Girbe [1 ,2 ]
Denham, Emma L. [1 ,2 ]
机构：
[1] Univ Med Ctr Groningen, Dept Med Microbiol, NL-9700 RB Groningen, Netherlands
[2] Univ Groningen, NL-9700 RB Groningen, Netherlands
[3] Pepscan Therapeut BV, NL-8203 AB Lelystad, Netherlands
来源：
JOURNAL OF BACTERIOLOGY | 2011年 / 193卷 / 05期
关键词：
CHROMOSOME MEC SCCMEC; VIRULENCE-DETERMINANT EXPRESSION; PHENOL-SOLUBLE MODULINS; GENE-EXPRESSION; NUCLEOTIDE-SEQUENCE; SIGNAL-TRANSDUCTION; GENOME SEQUENCE; DELTA-HEMOLYSIN; REGULATOR AGR; IN-VIVO;
D O I：
10.1128/JB.01276-10
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The important human pathogen Staphylococcus aureus is known to spread on soft agar plates. Here, we show that colony spreading of S. aureus involves the agr quorum-sensing system. This finding can be related to the agr-dependent expression of biosurfactants, such as phenol-soluble modulins, suggesting a connection between spreading motility and virulence.
引用
收藏
页码：1267 / 1272
页数：6
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