pH-Responsive near-infrared fluorescent cyanine dyes for molecular imaging based on pH sensing

被引：38
作者：
Miki, Koji [1 ]
Kojima, Kentaro [1 ]
Oride, Kazuaki [1 ]
Harada, Hiroshi [2 ]
Morinibu, Akiyo [2 ]
Ohe, Kouichi [1 ]
机构：
[1] Kyoto Univ, Grad Sch Engn, Dept Energy & Hydrocarbon Chem, Nishikyo Ku, Kyoto 6158510, Japan
[2] Kyoto Univ, Ctr Radiat Biol, Canc Cell Biol Lab, Sakyo Ku, Yoshida Konoe Cho, Kyoto 6068501, Japan
来源：
CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 55期
基金：
日本科学技术振兴机构;
关键词：
TUMORS IN-VIVO; BIOLOGICAL APPLICATIONS; OPTICAL-PROPERTIES; INDOCYANINE GREEN; PROBES; CELLS; NANOPARTICLES; CARBOCYANINE; LIFETIME; REGIONS;
D O I：
10.1039/c7cc03035e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Indocyanine green (ICG) derivatives having nucleophilic substituents were synthesized as pH-responsive near-infrared dyes. pH-responsive dyes 1-C with closed-ring structures smoothly internalized and converted to emissive open-ring structures 1-O in response to relatively low pHs in acidic intracellular compartments of HeLa cells.
引用
收藏
页码：7792 / 7795
页数：4
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