Reinfection With SARS-CoV-2: Implications for Vaccines

被引：80

作者：

Cohen, Jeffrey, I ^{[1
]}

Burbelo, Peter D. ^{[2
]}

机构：

[1] NIH, Lab Infect Dis, Bldg 50,Room 6134,50 South Dr,MSC8007, Bethesda, MD 20892 USA

[2] Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD USA

来源：

CLINICAL INFECTIOUS DISEASES | 2021年 / 73卷 / 11期

基金：

美国国家卫生研究院;

关键词：

SARS-CoV-2; COVID-19; reinfection; coronavirus; SARS; HUMORAL IMMUNITY; CORONAVIRUS; INFECTIONS; ANTIBODIES; VIRUS;

D O I：

10.1093/cid/ciaa1866

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become pandemic and the duration of protective immunity to the virus is unknown. Cases of persons reinfected with the virus are being reported with increasing frequency. At present it is unclear how common reinfection with SARS-CoV-2 is and how long serum antibodies and virus-specific T cells persist after infection. For many other respiratory virus infections, including influenza and the seasonal coronaviruses that cause colds, serum antibodies persist for only months to a few years and reinfections are very common. Here we review what is known about the duration of immunity and reinfection with coronaviruses, including SARS-CoV-2, as well as the duration of immunity to other viruses and virus vaccines. These findings have implications for the need of continued protective measures and for vaccines for persons previously infected with SARS-CoV-2.

引用

页码：E4223 / E4228

页数：6

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