Serum interleukin-18 binding protein increases with behavior different from IL-18 in patients with diabetic nephropathy

被引：15
作者：
Fujita, Takayuki [1 ]
Shimizu, Chie [1 ]
Fuke, Yoshinobu [1 ]
Satomura, Atsushi [2 ]
Abe, Masanori [1 ]
Kaizu, Kazo [3 ]
Matsumoto, Koichi [4 ]
Soma, Masayoshi [1 ,5 ]
机构：
[1] Nihon Univ, Sch Med, Dept Nephrol Hypertens & Endocrinol, Itabashi Ku, Tokyo 1738610, Japan
[2] Nihon Univ, Sch Med, Dept Lab Med, Tokyo 1738610, Japan
[3] Yokohama Social Insurance Cent Hosp, Dept Nephrol & Blood Purificat, Yokohama, Kanagawa, Japan
[4] Nihon Univ, Sch Med, Univ Res Ctr, Tokyo 1738610, Japan
[5] Nihon Univ, Sch Med, Dept Gen Med, Tokyo 1738610, Japan
来源：
DIABETES RESEARCH AND CLINICAL PRACTICE | 2011年 / 92卷 / 03期
关键词：
Interleukin; 18; Interleukin 18 binding protein; Micro-inflammation; Diabetic nephropathy; Type 2 diabetes mellitus; INFLAMMATION; DYSFUNCTION; CYTOKINE; TH1;
D O I：
10.1016/j.diabres.2011.02.028
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We investigated alterations between serum interleukin 18 (IL-18) and IL-18 binding protein (18BP) in T2DM patients. 18 BP began to increase after IL-18 increased and reached a threshold, in which case kidney dysfunction would have developed. These data indicate that 18BP might express glomerular dysfunction more closely than IL-18. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：E66 / E69
页数：4
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